The effect of endurance training on protein-D surfactant (SPD) and insulin resistance index in type 2 diabetic rats

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SALEHIKIA ABBAS; PARASTESH MOHAMMAD

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Journal: Journal of Sabzevar University of Medical Sciences Year:2019 | Volume:26 | Issue:1 Page(s): 89-97

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Information Journal Paper

Title

The effect of endurance training on protein-D surfactant (SPD) and insulin resistance index in type 2 diabetic rats

Author(s)

SALEHIKIA ABBAS | PARASTESH MOHAMMAD | Issue Writer Certificate

Keywords

insulinQ1

streptozotocin–nicotinamideQ1

surfactant protein-DQ2

trainingQ1

Abstract

Background & Objectives The aim of present study was to investigate effects of endurance training on surfactant protein-D in streptozotocin– nicotinamide induced diabetic rats. Materials & Methods In this experimental study, 36 adult male Wistar rats in the weight range of 200± 48 gr, randomly assigned in to four groups: healthy control, diabetic control, diabetic endurance training and healthy endurance training. For induction of diabetes, intraperitoneal injection of nicotinamide solution (120 mg/kg) and STZ solution (65 mg/kg) was used. The endurance training protocol was performed for 8-week and 24 hours. After the last training session blood serum samples were examined for evaluating reproductive hormones. Data were analyzed using one-way ANOVA and Turkey’ s Post Hoc test at 0. 05%. Results Endurance training caused a significant decrease in blood glucose in the endurance diabetic training group compared to the diabetic control group (p=0. 000). Serum Protein-D Surfactant (SPD) serum levels in the diabetic control group significantly decreased (p=0. 001) and the insulin resistance index (p=0. 000) was significantly lower than healthy controls. Eight weeks of endurance training significantly increased in SPD (p=0. 041) in endurance diabetic training group compared to diabetic control group. Also, exercise significantly decreased insulin resistance index (p=0. 000) and insulin (p=0. 029) in endurance diabetic training group compared to diabetic control group. Conclusion It seems that endurance training by increasing the levels of serum SPD improve insulin resistance index in type 2 diabetic mice.

Cites

Effect of 8-Week Endurance Training on the Content of Mtor and SREBP1 Proteins in Subcutaneous Fat Tissue in Obese Type 2 Diabetic Male Sprague-Dawley Rats

References

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APA: Copy

SALEHIKIA, ABBAS, & PARASTESH, MOHAMMAD. (2019). The effect of endurance training on protein-D surfactant (SPD) and insulin resistance index in type 2 diabetic rats. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 26(1 ), 89-97. SID. https://sid.ir/paper/82160/en

Vancouver: Copy

SALEHIKIA ABBAS, PARASTESH MOHAMMAD. The effect of endurance training on protein-D surfactant (SPD) and insulin resistance index in type 2 diabetic rats. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;26(1 ):89-97. Available from: https://sid.ir/paper/82160/en

IEEE: Copy

ABBAS SALEHIKIA, and MOHAMMAD PARASTESH, “The effect of endurance training on protein-D surfactant (SPD) and insulin resistance index in type 2 diabetic rats,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 1 , pp. 89–97, 2019, [Online]. Available: https://sid.ir/paper/82160/en

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