The effect of exercise training type on 8-oxoguanine DNA glycosylase and 8-hydroxy-2'-deoxyguanosine levels in the brain and liver of rats

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TAHERI CHADORNESHIN HOSSEIN; AFZALPOUR MOHAMMAD ESMAIEL; Afroozi Gerow Ehsan; ABTAHI EIVARY SEYED HOSEIN; ALIPOUR RAZ MEYSAM

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Journal: Journal of Sabzevar University of Medical Sciences Year:2019 | Volume:26 | Issue:1 Page(s): 99-107

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Title

The effect of exercise training type on 8-oxoguanine DNA glycosylase and 8-hydroxy-2'-deoxyguanosine levels in the brain and liver of rats

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Keywords

brainQ1

endurance trainingQ1

8-hydroxy-2'-deoxyguanosineQ2

8-oxoguanine DNA glycosylaseQ2

liverQ2

ratQ2

sprint trainingQ2

Abstract

Background & Objectives Reactive oxygen specie (ROS) results in serious damage oxidation of proteins, lipids and genomic structures. Studies have shown that production of ROS increases during intensive exercise training. Materials & Methods The aim of current study was to investigate the effect of two types sprint and endurance exercise trainings on 8-oxoguanine DNA glycosylase (OGG1) and hydroxy-2'-deoxyguanosine (8-OHdG) levels in the brain and liver of Wistar rats. 24 adult Albino Wistar rats were randomly divided into sedentary control, sprint, and endurance exercise training groups. rats in sprint and endurance exercise training groups ran on treadmill for six weeks, six days per week, at 80% to 100% of maximal oxygen consumption. OGG1 and 8-OHdG levels were measured using sandwich ELISA assay. Data analyzed using one way ANOVA at p≤ 0. 05 level. Results Results showed that both of sprint and endurance exercise trainings result in significant increase in OGG1 levels in brain and liver. Sprint exercise training resulted in greater increase in brain OGG1 than endurance exercise training. However, sprint and endurance exercise trainings had no significant effect on 8-OHdG levels in brain and liver tissues. Conclusion OGG1 content correlated negatively with 8-OHdG levels. Collectively, sprint and endurance exercise trainings prevent from genomic structure through an increase in OGG1 contents.

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APA: Copy

TAHERI CHADORNESHIN, HOSSEIN, AFZALPOUR, MOHAMMAD ESMAIEL, Afroozi Gerow, Ehsan, ABTAHI EIVARY, SEYED HOSEIN, & ALIPOUR RAZ, MEYSAM. (2019). The effect of exercise training type on 8-oxoguanine DNA glycosylase and 8-hydroxy-2'-deoxyguanosine levels in the brain and liver of rats. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 26(1 ), 99-107. SID. https://sid.ir/paper/82162/en

Vancouver: Copy

TAHERI CHADORNESHIN HOSSEIN, AFZALPOUR MOHAMMAD ESMAIEL, Afroozi Gerow Ehsan, ABTAHI EIVARY SEYED HOSEIN, ALIPOUR RAZ MEYSAM. The effect of exercise training type on 8-oxoguanine DNA glycosylase and 8-hydroxy-2'-deoxyguanosine levels in the brain and liver of rats. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;26(1 ):99-107. Available from: https://sid.ir/paper/82162/en

IEEE: Copy

HOSSEIN TAHERI CHADORNESHIN, MOHAMMAD ESMAIEL AFZALPOUR, Ehsan Afroozi Gerow, SEYED HOSEIN ABTAHI EIVARY, and MEYSAM ALIPOUR RAZ, “The effect of exercise training type on 8-oxoguanine DNA glycosylase and 8-hydroxy-2'-deoxyguanosine levels in the brain and liver of rats,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 1 , pp. 99–107, 2019, [Online]. Available: https://sid.ir/paper/82162/en

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