THE EFFECT OF HYDROCORTISOLE ON ANXIETY REAETIONS OF MICE

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VAFAEI ABAS ALI; TAHERIAN ABAS ALI

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Paper Information

Journal: Journal of Sabzevar University of Medical Sciences Year:2008 | Volume:14 | Issue:4 (46) Page(s): 192-197

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Title

THE EFFECT OF HYDROCORTISOLE ON ANXIETY REAETIONS OF MICE

Author(s)

VAFAEI ABAS ALI | TAHERIAN ABAS ALI | Issue Writer Certificate

Keywords

ANXIETYQ2

GLUCOCORTICOIDSQ2

HYDROCORTISOLEQ3

MICEQ2

Abstract

Background and purpose: One of the factors relations to ANXIETY is the change in endocrine hormones. Previous studies suggest that GLUCOCORTICOIDS might have a modulatory role in fear and ANXIETY. Therefore, the present study was designed to determine the role of HYDROCORTISOLE in modulating the MICE ANXIETY in elevated plus maze.Material and Methods: In this experimental study, 70 male MICE (25-30 gr). Were randomly assigned into test, sham and control groups. The test MICE received different doses of HYDROCORTISOLE (10, 25, 50, 75 and 100 mg/kg, S.C) as the agonist receptor of GLUCOCORTICOIDS; the sham group received the same volume of ethanol 2% plus saline, which was injected 30 minutes prior to ANXIETY assessment. The control group receined nothing. In order to increase the animals, activity and curiosity, they were led into a black box with checked walls for 5 minutes. Then, each animal was taken to the maze (a standard device for research purposes) at regular intervals. Evaluation indexes and ANXIETY reactions (frequency of entening into open armr and the time spent) were observed and recorded.Results: the results indicated that HYDROCORTISOLE (20 and 50 mg) had significantly increased the frequency and duration of entrance into open arms, which is a sign of reducing ANXIETY (P<0.01). but other doses (10, 75 and 100 mg) did not have significant effects.Conclusion: The finding revealed that dose-dependent HYDROCORTISOLE had an important role in modulating ANXIETY reactions of MICE in the elevated plus maze model.

Cites

ASSESSMENT OF THE EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF TRIGONELLA FOENUM ON ANXIETY AND SLEEP IN MICE

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APA: Copy

VAFAEI, ABAS ALI, & TAHERIAN, ABAS ALI. (2008). THE EFFECT OF HYDROCORTISOLE ON ANXIETY REAETIONS OF MICE. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 14(4 (46)), 192-197. SID. https://sid.ir/paper/82479/en

Vancouver: Copy

VAFAEI ABAS ALI, TAHERIAN ABAS ALI. THE EFFECT OF HYDROCORTISOLE ON ANXIETY REAETIONS OF MICE. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2008;14(4 (46)):192-197. Available from: https://sid.ir/paper/82479/en

IEEE: Copy

ABAS ALI VAFAEI, and ABAS ALI TAHERIAN, “THE EFFECT OF HYDROCORTISOLE ON ANXIETY REAETIONS OF MICE,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 14, no. 4 (46), pp. 192–197, 2008, [Online]. Available: https://sid.ir/paper/82479/en

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