INVESTIGATING THE EFFECTS OF CO-TREATMENT OF TYPE ONE INTERFERONS AND GRANULOCYTE COLONY-STIMULATING FACTOR ON GLUCOSE, TRIGLYCERIDES AND CHOLESTEROL OF BLOOD SERUM IN SYRIAN MOUSE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NAMJU ENSIYE; LARI ROYA; MAHDAVI SHAHRI NASSER; MOGHIMI ALI; ROJHAN NEZHAD MEHRNEGAR; IZI LEILA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Sabzevar University of Medical Sciences Year:2018 | Volume:25 | Issue:1 Page(s): 93-100

Download Full-Text

Persian Verion

View:

513

Download:

Cites:

Information Journal Paper

Title

INVESTIGATING THE EFFECTS OF CO-TREATMENT OF TYPE ONE INTERFERONS AND GRANULOCYTE COLONY-STIMULATING FACTOR ON GLUCOSE, TRIGLYCERIDES AND CHOLESTEROL OF BLOOD SERUM IN SYRIAN MOUSE

Author(s)

Keywords

BLOOD BIOCHEMICAL PARAMETERSQ1

G-CSFQ2

IFN-αQ2

IFN-βQ1

INFLAMMATIONQ1

Abstract

Backgrond: Granulocyte colony-stimulating factor (G-CSF) widely has been used in treatment of chemotherapy-induced neutropenia. Different lines of evidence indicated that G-CSF is increased in inflammatory situation and has inflammatory characteristics. Unlike G-CSF, type I interferones (IFNs) have been shown to have anti-inflammatory effects and therapeutic effects of them in inflammatory diseases such as hepatitis and multiple sclerosis is known. The aim of this study was to investigate the effects of G-CSF on blood factors and also whether type I IFNs can normalize the probable effects of G-CSF on blood factors.Materials and Methods: 42 mice (male, eight weeks) were divided into six groups of seven, which includes Group 1: (control) injection of distilled water, Group 2: injection 200 mg/kg body weight (b.w.) G-CSF, Group 3: injection 200 mg/kg b.w. interferon-a (IFN-a), Group 4: injection 200 mg/kg b.w. interferon beta (IFN-b), Group 5: injection 200 mg/kg b.w. G-CSF+200 mg/kg b.w. IFN-a, and Group 6: injection 200 mg/kg b.w. G-CSF+200 mg/kg b.w. IFN-b. After 28 days, blood was taken from each mouse heart and BLOOD BIOCHEMICAL PARAMETERS (glucose, triglyceride, cholestrol) was investigated.Results: surprisingly, in most cases, the G-CSF and type one IFNs alone or simultaneously reduced the levels of glucose, triglycerides and cholesterol. Also, the reduction of glucose, triglycerides and cholesterol were higher in G-CSF and IFNs in compare with G-CSF alone. Our data raise the possibility that, G-CSF and IFN-α/β have some similarity in signaling pathway which has to be investigated.

Cites

No record.

References

Hypercholesterolemia and microvascular dysfunction: interventional strategies

Cite

APA: Copy

NAMJU, ENSIYE, LARI, ROYA, MAHDAVI SHAHRI, NASSER, MOGHIMI, ALI, ROJHAN NEZHAD, MEHRNEGAR, & IZI, LEILA. (2018). INVESTIGATING THE EFFECTS OF CO-TREATMENT OF TYPE ONE INTERFERONS AND GRANULOCYTE COLONY-STIMULATING FACTOR ON GLUCOSE, TRIGLYCERIDES AND CHOLESTEROL OF BLOOD SERUM IN SYRIAN MOUSE. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 25(1 ), 93-100. SID. https://sid.ir/paper/82510/en

Vancouver: Copy

NAMJU ENSIYE, LARI ROYA, MAHDAVI SHAHRI NASSER, MOGHIMI ALI, ROJHAN NEZHAD MEHRNEGAR, IZI LEILA. INVESTIGATING THE EFFECTS OF CO-TREATMENT OF TYPE ONE INTERFERONS AND GRANULOCYTE COLONY-STIMULATING FACTOR ON GLUCOSE, TRIGLYCERIDES AND CHOLESTEROL OF BLOOD SERUM IN SYRIAN MOUSE. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;25(1 ):93-100. Available from: https://sid.ir/paper/82510/en

IEEE: Copy

ENSIYE NAMJU, ROYA LARI, NASSER MAHDAVI SHAHRI, ALI MOGHIMI, MEHRNEGAR ROJHAN NEZHAD, and LEILA IZI, “INVESTIGATING THE EFFECTS OF CO-TREATMENT OF TYPE ONE INTERFERONS AND GRANULOCYTE COLONY-STIMULATING FACTOR ON GLUCOSE, TRIGLYCERIDES AND CHOLESTEROL OF BLOOD SERUM IN SYRIAN MOUSE,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 1 , pp. 93–100, 2018, [Online]. Available: https://sid.ir/paper/82510/en

Related Journal Papers