THE EFFECT OF HORMONE REPLACEMENT THERAPY WITH CALCIUM PLUS VITAMIN-D ON OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN

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TAVASOULI F.; Shairfian Attar j.; RAJABIAN R.

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Paper Information

Journal: Journal of Sabzevar University of Medical Sciences Year:2002 | Volume:9 | Issue:2 (24) Page(s): 29-36

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Title

THE EFFECT OF HORMONE REPLACEMENT THERAPY WITH CALCIUM PLUS VITAMIN-D ON OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN

Author(s)

TAVASOULI F. | Shairfian Attar j. | RAJABIAN R. | Issue Writer Certificate

Keywords

HORMONE REPLACEMENT THERAPYQ3

OSTEOPOROSISQ3

MENOPAUSAL WOMENQ4

DENSITOMETRYQ2

CALCIUM PLUS VITAMIN-DQ3

Abstract

Postmeopausal estrogen replacement therapy prevents the development of OSTEOPOROSIS and reduces the risk of fracture. The amount of bone density reduction in in women without this kind of therapy is 3% per year. Resaearch has shown that the bone density of Iranian healthy women is 6.5% in lumbar spine and 5.4% in femoral neck which are quite lower than those of the white women and hence are predisposed to osteopoprosis. This prospective randomized clinical trial involved 100 women (45-55 years old) divided into two groups: group one received 0.625 mg tablet conjugated estrogen and 2.5 medroxy progesterone plus two calcium (500 mg) and vitamin D (200 unit) daily. The subjects were randomly selected by population proportion and were tested for their Routine Hormone Assay and clinical evaluation. Their BMD were estimated by dual energy X-ray absorptometetry (DEXA) for L2-L4 spine and neck of femor before and about a year after the treatment. No significant difference was found to exist in the bone mineral density of L2-L4 spine and neck of the femor in the two groups before the treatment but t-test showed that there was a significant difference as for the BMD recovery of the groups after the treatment (p<0.0001). BMD of the subjects treated with HRT had improved but that of the CALCIUM PLUS VITAMIN-D group had diminished after a year. Therefore, it is clear that calcium and vitamin D treatment is not sufficient to prevent OSTEOPOROSIS in women. This study revealed that estrogen replacement therapy (ERT) along with CALCIUM PLUS VITAMIN-D increased BMD in postmenopausal women.

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References

EFFECT OF SUPPRESSIVE THERAPY WITH LEVOTHYROXINE ON BONE MINERAL DENSITY IN PREMENOPAUSAL WOMEN

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APA: Copy

TAVASOULI, F., Shairfian Attar, j., & RAJABIAN, R.. (2002). THE EFFECT OF HORMONE REPLACEMENT THERAPY WITH CALCIUM PLUS VITAMIN-D ON OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 9(2 (24)), 29-36. SID. https://sid.ir/paper/82675/en

Vancouver: Copy

TAVASOULI F., Shairfian Attar j., RAJABIAN R.. THE EFFECT OF HORMONE REPLACEMENT THERAPY WITH CALCIUM PLUS VITAMIN-D ON OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2002;9(2 (24)):29-36. Available from: https://sid.ir/paper/82675/en

IEEE: Copy

F. TAVASOULI, j. Shairfian Attar, and R. RAJABIAN, “THE EFFECT OF HORMONE REPLACEMENT THERAPY WITH CALCIUM PLUS VITAMIN-D ON OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 9, no. 2 (24), pp. 29–36, 2002, [Online]. Available: https://sid.ir/paper/82675/en

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