DETERMINING THE DIAGNOSTIC VALUE LEVEL OF ALKALINE PHOSPHATES IN COMPARISON WITH PARATHYROID HORMONE (PTH) OF RENAL OSTEODYSTROPHY FOR TREATMENT WITH CALCITRIOL IN HEMODIALYSIS PATIENTS

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NOURI MAJELAN N.; SANADGOL H.

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Journal: Zahedan Journal of Research in Medical Sciences Year:2007 | Volume:8 | Issue:4 Page(s): 239-244

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Title

DETERMINING THE DIAGNOSTIC VALUE LEVEL OF ALKALINE PHOSPHATES IN COMPARISON WITH PARATHYROID HORMONE (PTH) OF RENAL OSTEODYSTROPHY FOR TREATMENT WITH CALCITRIOL IN HEMODIALYSIS PATIENTS

Author(s)

NOURI MAJELAN N. | SANADGOL H. | Issue Writer Certificate

Keywords

RENAL DIALYSISQ3

RENAL OSTEODYSTROPHYQ3

PARATHYROID HORMONEQ3

ALKALINE HOSPHATASQ2

Abstract

Background: Serum PARATHYROID HORMONE (PTH) is one of the most important tests for treatment of hemodialysis patients with calcitriol. This drug should be started when the PTH³200 pg/ml. However, the appropriate level of serum alkaline phosphates (ALP) for starting calcitriol is unclear. The aim of this study was to determine a serum ALP as cutoff point for treatment of secondary hyperparathyroidism with calcitriol.Method and Material: This was a cross sectional study. The serum level of PTH and ALP was measured in 75 chronic hemodialysis patients.Results: The correlation between PTH and ALP in diagnosis for treatment with calcitriol was significant (Kappa test P-Value=0.000). In determination of diagnostic value of ALP (at level 300IU/L) for treatment with calcitriol, sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 88.9%, 93.9%, 66.7%, 98.4% and 93.3%, respectively. The cutoff point of ALP for treatment with calcitriol was 300 IU/L (normal 100-290 IU/L(Conclusion: These findings suggest that serum ALP is a good test for treatment of secondary hyperparathyroidism. The results also indicate that calcitriol administration should not be started with ALP<300 IU/L.

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APA: Copy

NOURI MAJELAN, N., & SANADGOL, H.. (2007). DETERMINING THE DIAGNOSTIC VALUE LEVEL OF ALKALINE PHOSPHATES IN COMPARISON WITH PARATHYROID HORMONE (PTH) OF RENAL OSTEODYSTROPHY FOR TREATMENT WITH CALCITRIOL IN HEMODIALYSIS PATIENTS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 8(4), 239-244. SID. https://sid.ir/paper/84424/en

Vancouver: Copy

NOURI MAJELAN N., SANADGOL H.. DETERMINING THE DIAGNOSTIC VALUE LEVEL OF ALKALINE PHOSPHATES IN COMPARISON WITH PARATHYROID HORMONE (PTH) OF RENAL OSTEODYSTROPHY FOR TREATMENT WITH CALCITRIOL IN HEMODIALYSIS PATIENTS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2007;8(4):239-244. Available from: https://sid.ir/paper/84424/en

IEEE: Copy

N. NOURI MAJELAN, and H. SANADGOL, “DETERMINING THE DIAGNOSTIC VALUE LEVEL OF ALKALINE PHOSPHATES IN COMPARISON WITH PARATHYROID HORMONE (PTH) OF RENAL OSTEODYSTROPHY FOR TREATMENT WITH CALCITRIOL IN HEMODIALYSIS PATIENTS,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 8, no. 4, pp. 239–244, 2007, [Online]. Available: https://sid.ir/paper/84424/en

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