EPIGENETIC MECHANISMS IN THE INITIATION OF HEMATOLOGICAL MALIGNANCIES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MALEKI ALI; KAVIANI SAEID; NORUZINIA MEHRDAD; FARSHDOOSTI HAGH MAJID; KAVIANI ZEINAB; MANSOURI KAMRAN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Zahedan Journal of Research in Medical Sciences Year:2011 | Volume:13 | Issue:5 Page(s): 1-7

Download Full-Text

Persian Verion

View:

5,939

Download:

Cites:

Information Journal Paper

Title

EPIGENETIC MECHANISMS IN THE INITIATION OF HEMATOLOGICAL MALIGNANCIES

Author(s)

Keywords

EPIGENETICQ2

HEMATOLOGICAL NEOPLASMSQ2

METHYLATIONQ1

HISTONEQ2

Abstract

Background: Cancer development is not restricted to the genetic changes, but also to EPIGENETIC changes. EPIGENETIC processes are very important in the development of hematological malignancies. The main EPIGENETIC alterations are aberrations in DNA METHYLATION, post-translational modifications of HISTONEs, chromatin remodeling and microRNAs patterns, and these are associated with tumor genesis. All the various cellular pathways contributing to the neoplastic phenotype are affected by EPIGENETIC genes in cancer. These pathways can be explored as biomarkers in clinical use for early detection of disease, malignancy classification and response to treatment with classical chemotherapy agents and EPIGENETIC drugs.Materials and Method: A literature review was performed using PUBMED from 1985 to 2008. Cross referencing of discovered articles was also reviewed.Results: In chronic lymphocytic leukemia, regional hypermethylation of gene promoters leads to gene silencing.Many of these genes have tumor suppressor phenotypes. In myelodysplastic syndrome (MDS), CDKN2B (alias, P15), a cyclin-dependent kinase inhibitor that negatively regulates the cell cycle, has been shown to be hypermethylated in marrow stem (CD34+) cells in patients with MDS. At present both Vidaza and Decitabine (DNA methyltransferase inhibitors) are approved for the treatment of MDS.Conclusion: Unlike mutations or deletions, DNA hypermethylation and HISTONE deacetylation are potentially reversible by pharmacological inhibition, therefore those EPIGENETIC changes have been recognized as promising novel therapeutic targets in hematopoietic malignances. In this review, we discussed molecular mechanisms of EPIGENETICs, EPIGENETIC changes in hematological malignancies and EPIGENETIC based treatments.

Cites

No record.

References

No record.

Cite

APA: Copy

MALEKI, ALI, KAVIANI, SAEID, NORUZINIA, MEHRDAD, FARSHDOOSTI HAGH, MAJID, KAVIANI, ZEINAB, & MANSOURI, KAMRAN. (2011). EPIGENETIC MECHANISMS IN THE INITIATION OF HEMATOLOGICAL MALIGNANCIES. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 13(5), 1-7. SID. https://sid.ir/paper/84589/en

Vancouver: Copy

MALEKI ALI, KAVIANI SAEID, NORUZINIA MEHRDAD, FARSHDOOSTI HAGH MAJID, KAVIANI ZEINAB, MANSOURI KAMRAN. EPIGENETIC MECHANISMS IN THE INITIATION OF HEMATOLOGICAL MALIGNANCIES. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2011;13(5):1-7. Available from: https://sid.ir/paper/84589/en

IEEE: Copy

ALI MALEKI, SAEID KAVIANI, MEHRDAD NORUZINIA, MAJID FARSHDOOSTI HAGH, ZEINAB KAVIANI, and KAMRAN MANSOURI, “EPIGENETIC MECHANISMS IN THE INITIATION OF HEMATOLOGICAL MALIGNANCIES,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 13, no. 5, pp. 1–7, 2011, [Online]. Available: https://sid.ir/paper/84589/en

Related Journal Papers