EFFECT OF VITIS VINIFERA LEAF EXTRACT ON PER FUSED FROG HEART

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GHARIB NASERI MOHAMMAD KAZEM

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Journal: Zahedan Journal of Research in Medical Sciences Year:2004 | Volume:5 | Issue:4 Page(s): 227-235

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Title

EFFECT OF VITIS VINIFERA LEAF EXTRACT ON PER FUSED FROG HEART

Author(s)

GHARIB NASERI MOHAMMAD KAZEM | Issue Writer Certificate

Keywords

FROGQ4

HEARTQ4

VITIS VINIFERAQ3

CONTRACTILITYQ3

ACETYLCHOLINEQ3

VERAPAMILQ3

EPINEPHRINEQ3

Abstract

Vitis vinifera (grape) from Vitaceae and its leaves are used in traditional medicine to treat diarrhea, gout and varicosis. We have shown recently that, VITIS VINIFERA leaf hydroalcoholic extract (VLHE) reduces CONTRACTILITY of the rat ileum and uterus precontracted by KCl via voltage-dependent calcium channels (VDCCs). The aim of the present study was, therefore, to investigate the effect of VLHE on perfused FROG HEART rate and CONTRACTILITY. Extract was prepared by alcohol (70%) for 72 hours and after evaporation of solvent, the extract powder was obtained. Right aorta branch of pitted FROG was lighted and Ringer’s solution was per fused via vena cava. Perfusate was drained via the cannulated left aorta. Final extract concentrations were 0.25, 0.5, 1, 2 and 4 mg/ml. HEART CONTRACTILITY was recorded by an isotonic transducer under 1 g initial tension. The percentage of changes in HEART CONTRACTILITY and rate were calculated and presented as mean ± SEM. VLHE reduced the HEART rate and CONTRACTILITY dose-dependently and significantly. In more cases, the extract (2 mg/ml) caused cardiac arrest in diastolic. The effects of HEART electrical stimulation (1Hz, 10 V, 1ms, 10sec) and EPINEPHRINE (20μg/ml) were inhibited by VLHE significantly. Atropine (1μM) abolished the Ach (1μM) inhibitory effect on HEART but not of VLHE. Cardiac electrical stimulation was effective on HEART in presence of VERAPAMIL (1μM) but not in the presence of VLHE. In has been concluded that, the negative inotropic and chronotropic effects of VLHE were not through cholinergic system and probably, the inhibitory effects are induced via blockade of VDCCs.

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References

EFFECT OF HYDROALCOHOLIC ZIZYPHUS SPINA CHRISTI FRUIT EXTRACT ON THE RATE AND CONTRACTILITY OF PERFUSED FROG HEART

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APA: Copy

GHARIB NASERI, MOHAMMAD KAZEM. (2004). EFFECT OF VITIS VINIFERA LEAF EXTRACT ON PER FUSED FROG HEART. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 5(4), 227-235. SID. https://sid.ir/paper/84619/en

Vancouver: Copy

GHARIB NASERI MOHAMMAD KAZEM. EFFECT OF VITIS VINIFERA LEAF EXTRACT ON PER FUSED FROG HEART. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2004;5(4):227-235. Available from: https://sid.ir/paper/84619/en

IEEE: Copy

MOHAMMAD KAZEM GHARIB NASERI, “EFFECT OF VITIS VINIFERA LEAF EXTRACT ON PER FUSED FROG HEART,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 5, no. 4, pp. 227–235, 2004, [Online]. Available: https://sid.ir/paper/84619/en

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