FURAZOLIDONE A HIGHLY EHECTIVE ANTIMICROBIAL AGAINST METRONIDAZOLE RESISTANT STRAINS OF H.PYLORI

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SAFARALIZADEH R.; SIAVASHI F.; MALEKZADEH R.; DERAKHSHAN M.H.; SOHRABI MASOUD REZA; MAHDAVINIA M.; MASARAT S.

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Journal: GOVARESH JOURNAL Year:2003 | Volume:7 | Issue:41 Page(s): 153-158

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Title

FURAZOLIDONE A HIGHLY EHECTIVE ANTIMICROBIAL AGAINST METRONIDAZOLE RESISTANT STRAINS OF H.PYLORI

Author(s)

Keywords

HELICOBACTERPYLOTIQ3

RESISTANCEQ3

METRONIDAZOLEQ3

FURAZOLIDONEQ4

Abstract

Introduction: Eradication of H. pylori with the quadruple regimen, consisting of a proton pump inhibitor, bismuth salt, amoxicllin, and metronidazde has been successful in Iran. However occurrence of resistant strains to metronidazde leads to failure of this regimen. In such cases recruitment of a substitute for rpetranidazole appears inevitable.Material and methods: FURAZOLIDONE efficacy was compared to METRONIDAZOLE, clarithromycin, amoxicillin, and tetracycline in 70 H.pylori isolates from dyspeptic patients in vitro.Results: Thirty three percent of the isolates exhibited RESISTANCE to METRONIDAZOLE but all were susceptible to FURAZOLIDONE.Conclusion: It appears that no cross RESISTANCE appears between METRONIDAZOLE and FURAZOLIDONE, indicating that H.pylori strains do not acquire FURAZOLIDONE RESISTANCE phenotype as readily as METRONIDAZOLE RESISTANCE. The results of this study suggest that FURAZOLIDONE could be considered as an appropriate substitute for METRONIDAZOLE.

Cites

COMPARISON OF 7 DAYS VERSUS 14 DAYS TREATMENT WITH CLARITHROMYCIN, AMOX1CILINAND OMEPRAZOLE FOR ERADICATION OF HELICOBACTER PYLORI

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APA: Copy

SAFARALIZADEH, R., SIAVASHI, F., MALEKZADEH, R., DERAKHSHAN, M.H., SOHRABI, MASOUD REZA, MAHDAVINIA, M., & MASARAT, S.. (2003). FURAZOLIDONE A HIGHLY EHECTIVE ANTIMICROBIAL AGAINST METRONIDAZOLE RESISTANT STRAINS OF H.PYLORI. GOVARESH JOURNAL, 7(41), 153-158. SID. https://sid.ir/paper/86252/en

Vancouver: Copy

SAFARALIZADEH R., SIAVASHI F., MALEKZADEH R., DERAKHSHAN M.H., SOHRABI MASOUD REZA, MAHDAVINIA M., MASARAT S.. FURAZOLIDONE A HIGHLY EHECTIVE ANTIMICROBIAL AGAINST METRONIDAZOLE RESISTANT STRAINS OF H.PYLORI. GOVARESH JOURNAL[Internet]. 2003;7(41):153-158. Available from: https://sid.ir/paper/86252/en

IEEE: Copy

R. SAFARALIZADEH, F. SIAVASHI, R. MALEKZADEH, M.H. DERAKHSHAN, MASOUD REZA SOHRABI, M. MAHDAVINIA, and S. MASARAT, “FURAZOLIDONE A HIGHLY EHECTIVE ANTIMICROBIAL AGAINST METRONIDAZOLE RESISTANT STRAINS OF H.PYLORI,” GOVARESH JOURNAL, vol. 7, no. 41, pp. 153–158, 2003, [Online]. Available: https://sid.ir/paper/86252/en

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