EFFECTS OF ALUMINUM ON CULTURED HUMAN EMBRYONIC ASTROCYTES AND APOPTOTIC GENE EXPRESSION

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AMINIZADEH N.; RAJABALIAN SAEID; HOSSEIN RAFAT

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Journal: Journal of Ilam University of Medical Sciences Year:2008 | Volume:16 | Issue:3 Page(s): 11-19

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Title

EFFECTS OF ALUMINUM ON CULTURED HUMAN EMBRYONIC ASTROCYTES AND APOPTOTIC GENE EXPRESSION

Author(s)

AMINIZADEH N. | RAJABALIAN SAEID | HOSSEIN RAFAT | Issue Writer Certificate

Keywords

ALUMINUMQ2

ASTROCYTEQ2

HUMAN EMBRYOQ3

CYTOTOXICITYQ3

Abstract

Introduction: ALUMINUM is the third most abundant element in the earth's crust .It plays a role in several neurodegenerative conditions including Alzheimer's disease. In this study, we investigated the effects of ALUMINUM on HUMAN EMBRYOnic ASTROCYTEs. Materials & methods: In this experimental study, we applied MTT techniques to investigate the effects of 3,9, and 12 days exposure to ALUMINUM on ASTROCYTE viability . Then, we used immunocytochemical techniques to identify apoptotic gene expression changes induced by ALUMINUM. We used Stata software to analyze the data. Findings: Our results showed that 3-days exposure to 1 and 1.5mm caused a- reduction in ASTROCYTEs viability, (P<0.01 , P<0.03). Low levels of ALUMINUM (500 and 100 mM) needed long-term exposure to become toxic to ASTROCYTEs),9 days for 500 and 12 days for 100 mM) (P=0.000). ALUMINUM didn't show any effects on apoptotic gene expression. Conclusion: Long-term exposure, even to low levels of ALUMINUM, was toxic for HUMAN EMBRYOnic ASTROCYTEs, but it seems that ALUMINUM does not alter apoptotic gene expression.

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APA: Copy

AMINIZADEH, N., RAJABALIAN, SAEID, & HOSSEIN, RAFAT. (2008). EFFECTS OF ALUMINUM ON CULTURED HUMAN EMBRYONIC ASTROCYTES AND APOPTOTIC GENE EXPRESSION . JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 16(3), 11-19. SID. https://sid.ir/paper/89960/en

Vancouver: Copy

AMINIZADEH N., RAJABALIAN SAEID, HOSSEIN RAFAT. EFFECTS OF ALUMINUM ON CULTURED HUMAN EMBRYONIC ASTROCYTES AND APOPTOTIC GENE EXPRESSION . JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2008;16(3):11-19. Available from: https://sid.ir/paper/89960/en

IEEE: Copy

N. AMINIZADEH, SAEID RAJABALIAN, and RAFAT HOSSEIN, “EFFECTS OF ALUMINUM ON CULTURED HUMAN EMBRYONIC ASTROCYTES AND APOPTOTIC GENE EXPRESSION ,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 3, pp. 11–19, 2008, [Online]. Available: https://sid.ir/paper/89960/en

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