EVALUATION OF ANALGESIC EFFECT OF FRITILLARIA IMPERIALIST AQUEOUS EXTRACT IN RATS COMPARED TO MORPHINE

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MARD S.A.; SHARIFI M.; FATHI MOGHADAM H.; NIESI N.

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Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2005 | Volume:13 | Issue:3 Page(s): 1-6

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Title

EVALUATION OF ANALGESIC EFFECT OF FRITILLARIA IMPERIALIST AQUEOUS EXTRACT IN RATS COMPARED TO MORPHINE

Author(s)

MARD S.A. | SHARIFI M. | FATHI MOGHADAM H. | NIESI N. | Issue Writer Certificate

Keywords

FRITILLARIA IMPERIALISTQ4

TAIL-FLICKQ4

ANALEGESIC EFFECTQ4

Abstract

Introduction: The aim of this study was to investigate the analgesic effect of FRITILLARIA IMPERIALIST compared that of to morphine.Materials & Methods: Forty male albino wistars (250-300g) were used. The animals were selected and studied randomly in four groups (n=10) as follows: Groups A, Band C were tested with the Aqueous Extract of FRITILLARIA IMPERIALIST Bulbs (AEFB) at doses of 50 , 100, and 200 mg/kg, po respectively. Group D was administered by morphine (2 mg/kg, S.c). To evaluate the possible analgesic effect of this plant the acute (Tail-Flick) pain model was used in male rats.Results: Administration of 50 and 100 mg/kg of AEFB in group A and B didn't show any effect in the Tail- Flick test. However, AEFB (200 mg/kg) in group C reduced the pain significantly (P<0.05). There was no significant difference between groups C and D.Conclusion: This study demonstrated that the AEFB has analgesic effect. It seems that the analgesic effect of AEFB was associated with the presence of some alkaloids such as impericine and forticine.

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APA: Copy

MARD, S.A., SHARIFI, M., FATHI MOGHADAM, H., & NIESI, N.. (2005). EVALUATION OF ANALGESIC EFFECT OF FRITILLARIA IMPERIALIST AQUEOUS EXTRACT IN RATS COMPARED TO MORPHINE. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 13(3), 1-6. SID. https://sid.ir/paper/90170/en

Vancouver: Copy

MARD S.A., SHARIFI M., FATHI MOGHADAM H., NIESI N.. EVALUATION OF ANALGESIC EFFECT OF FRITILLARIA IMPERIALIST AQUEOUS EXTRACT IN RATS COMPARED TO MORPHINE. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2005;13(3):1-6. Available from: https://sid.ir/paper/90170/en

IEEE: Copy

S.A. MARD, M. SHARIFI, H. FATHI MOGHADAM, and N. NIESI, “EVALUATION OF ANALGESIC EFFECT OF FRITILLARIA IMPERIALIST AQUEOUS EXTRACT IN RATS COMPARED TO MORPHINE,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 13, no. 3, pp. 1–6, 2005, [Online]. Available: https://sid.ir/paper/90170/en

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