Investigating the Cytotoxic Effect and Antioxidant Properties of Green Synthesized Silver Nanoparticles from the Root of Persicaria Bistorta on Human Liver Cancer Cell Line (Hep G2)

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Shali R.; NEAMATI A.; ARDALAN P.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Ilam University of Medical Sciences Year:2019 | Volume:26 | Issue:6 Page(s): 133-142

Download Full-Text

Persian Verion

View:

998

Download:

Cites:

Information Journal Paper

Title

Investigating the Cytotoxic Effect and Antioxidant Properties of Green Synthesized Silver Nanoparticles from the Root of Persicaria Bistorta on Human Liver Cancer Cell Line (Hep G2)

Author(s)

Shali R. | NEAMATI A. | ARDALAN P. | Issue Writer Certificate

Keywords

AntioxidantQ1

Silver nanoparticlesQ1

Persicaria bistortaQ1

CancerQ2

Abstract

Introduction: The use of nanoparticles to inhibit the growth and proliferation of Cancer cells is one of the achievements of the nanotechnology science. Studies have shown that Silver nanoparticles have cytotoxic effects on the growth of Cancerous cells. On the other hand, the Antioxidant properties of this nanoparticle have been proven in many studies. Therefore, in this investigation, Antioxidant capacity and cytotoxicity effects of Silver nanoparticles synthesized from Root of Persicaria bistorta L (Bi/Ag-NPs) on liver Cancer cells (HepG2) compared with normal skin cells (HDF) were studied. In addition, ABTS and DPPH free radical scavenging capacity of Bi/Ag-NPs was evaluated using colorimetric tests. Materials & Methods: In order to evaluate the cytotoxicity effects, first the Cancerous and normal cells were cultured and treated with various concentrations of Bi/Ag-NPs and finally, the cell survival rate was estimated using the MTT assay. The Antioxidant activity of Bi/Ag-NPs was evaluated according to the amount of ABTS and DPPH free radicals inhibition. Findings: The results showed that Bi/Ag-NPs inhibited Cancer cells with an IC50 value of about 3 μ g/ml, while at this concentration they were ineffective on normal cells (IC50: 50 μ g/ml). The scavenging of ABTS (IC50: 15 μ g / ml) and DPPH (IC50: 20 μ g/ml) free radicals confirmed the Antioxidant properties of Bi/Ag-NPs. Discussion & Conclusions: The cytotoxic and Antioxidant results show that Bi/Ag-NPs can be used as auxiliary agents for treating many diseases that are caused by oxidative stress and other biomedical applications.

Cites

No record.

References

Antimicrobial, Antioxidant and Cytotoxic Activity of Silver Nanoparticles Synthesized by Leaf Extract of Erythrina suberosa (Roxb. )

Cite

APA: Copy

Shali, R., NEAMATI, A., & ARDALAN, P.. (2019). Investigating the Cytotoxic Effect and Antioxidant Properties of Green Synthesized Silver Nanoparticles from the Root of Persicaria Bistorta on Human Liver Cancer Cell Line (Hep G2). JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 26(6 ), 133-142. SID. https://sid.ir/paper/90190/en

Vancouver: Copy

Shali R., NEAMATI A., ARDALAN P.. Investigating the Cytotoxic Effect and Antioxidant Properties of Green Synthesized Silver Nanoparticles from the Root of Persicaria Bistorta on Human Liver Cancer Cell Line (Hep G2). JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;26(6 ):133-142. Available from: https://sid.ir/paper/90190/en

IEEE: Copy

R. Shali, A. NEAMATI, and P. ARDALAN, “Investigating the Cytotoxic Effect and Antioxidant Properties of Green Synthesized Silver Nanoparticles from the Root of Persicaria Bistorta on Human Liver Cancer Cell Line (Hep G2),” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 6 , pp. 133–142, 2019, [Online]. Available: https://sid.ir/paper/90190/en

Related Journal Papers