INVESTIGATING THE ANTIBACTERIAL EFFECT OF METHANOL AND ACETONE EXTRACTS OF URTICA DIOICA AND ZATARIA MULTIﬂORA AGAINST METALLO BETA-LACTAMASE PRODUCING PSEUDOMONAS AERUGINOSA

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ROSHANI M.; HEYDARI M.; GODAEZI H.; HASHEMI A.; ESLAMI G.; YOSEFI N.

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Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2016 | Volume:24 | Issue:3 Page(s): 70-78

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Title

INVESTIGATING THE ANTIBACTERIAL EFFECT OF METHANOL AND ACETONE EXTRACTS OF URTICA DIOICA AND ZATARIA MULTIﬂORA AGAINST METALLO BETA-LACTAMASE PRODUCING PSEUDOMONAS AERUGINOSA

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Keywords

PSEUDOMONAS AERUGINOSAQ2

ANTIBIOTIC RESISTANCEQ1

URTICA DIOICAQ1

ZATARIA MULTIﬂQ1

ORAQ1

METALLO BETAQ1

LACTAMASEQ1

Abstract

Introduction: PSEUDOMONAS AERUGINOSA is a major cause of nosocomial infections. Different mechanisms of drug resistance and acquired-resistance genes from other bacteria, caused the treatment of infections of this opportunistic pathogen with serious problems. So even with the newer antibiotics, the treatment has failed. The use of medicinal plants is one way to develop antimicrobial agents. Given the widespread use of URTICA DIOICA and Zataria multi ﬂORAherbs in traditional medicine and the potential effects against many infectious agents are going to eveluate the antibacterial effect of methanoland acetone extracts of URTICA DIOICA and ZATARIA MULTIﬂORA against METALLO BETA-lactamase producing PSEUDOMONAS AERUGINOSA carring bla VIM and bla IMP genes.Materials & methods: This study was performed from October to February year 2014 on 448 burn patients hospitalized in Shahid Motahari Hospital, Tehran. For all MBL-producing strains, ANTIBIOTIC RESISTANCE by disk diffusion method were done according to CLSI guide lines.CDDT method for detection of MBL and PCR and Sequencing methods for Identification of METALLO BETA-lactamase gene, bla IMP and bla VIM, were used. The minimum inhibitory concentrations of antibiotics meropenem, cefe pime, ceftazidime, cefotaxime, ampicillin, piperacillin/ tazobactam and ceftriaxoneand the minimum inhibitory concentration of methanol and acetone extracts of URTICA DIOICA and ZATARIA MULTIﬂORA herbs were done based on agar dilution method.Findings: Among 83 imipenem resistant P.aeruginosa strains, 48 (57.9%) isolates produced MBL. PCR and sequencing methods confirmed that these strains were blaIMP-1positive genes, whereas none were positive for bla (VIM) genes. Hospitalized burn patients with MBL-producing P.aeruginosainfection had 4/48 (8.3%) mortality rate. It was demonstrated that URTICA DIOICA and ZATARIA MULTIﬂORA extracts had a significant antibacterial effect on regular and IMP-producing P. aeruginosa strains.Discussion & Conclusions: Prevalence of MBL-producing PSEUDOMONAS AERUGINOSA strains among patients is high. Also due to high resistance of chemical drugs, the use of medicinal plants such as URTICA DIOICA and ZATARIA MULTIﬂORA can be a better alternative for treatment, which requires further studies. In this study the extracts of U.dioica and Z. multiﬂORA had a high antibacterial effect against β-lactamase producing P. aeruginosa isolates.

Cites

INVESTIGATION THE EFFECT OF MICELLE NANOPARTICLES CONTAINING CURCUMIN ON CIPROFLOXACIN RESISTANT ISOLATES OF PSEUDOMONAS AERUGINOSA AND ON MEXC AND MEXD GENES EXPRESSION

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APA: Copy

ROSHANI, M., HEYDARI, M., GODAEZI, H., HASHEMI, A., ESLAMI, G., & YOSEFI, N.. (2016). INVESTIGATING THE ANTIBACTERIAL EFFECT OF METHANOL AND ACETONE EXTRACTS OF URTICA DIOICA AND ZATARIA MULTI?ORA AGAINST METALLO BETA-LACTAMASE PRODUCING PSEUDOMONAS AERUGINOSA. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 24(3), 70-78. SID. https://sid.ir/paper/90370/en

Vancouver: Copy

ROSHANI M., HEYDARI M., GODAEZI H., HASHEMI A., ESLAMI G., YOSEFI N.. INVESTIGATING THE ANTIBACTERIAL EFFECT OF METHANOL AND ACETONE EXTRACTS OF URTICA DIOICA AND ZATARIA MULTI?ORA AGAINST METALLO BETA-LACTAMASE PRODUCING PSEUDOMONAS AERUGINOSA. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;24(3):70-78. Available from: https://sid.ir/paper/90370/en

IEEE: Copy

M. ROSHANI, M. HEYDARI, H. GODAEZI, A. HASHEMI, G. ESLAMI, and N. YOSEFI, “INVESTIGATING THE ANTIBACTERIAL EFFECT OF METHANOL AND ACETONE EXTRACTS OF URTICA DIOICA AND ZATARIA MULTI?ORA AGAINST METALLO BETA-LACTAMASE PRODUCING PSEUDOMONAS AERUGINOSA,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 3, pp. 70–78, 2016, [Online]. Available: https://sid.ir/paper/90370/en

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