Cytokine Responses in BALB/c Mice Immunized with Ovalbumin after Oral Administration of 5-Hydroxymethylfurfural

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ALIZADEH M.; KHODAEI H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Journal of Ilam University of Medical Sciences Year:2018 | Volume:26 | Issue:1 Page(s): 34-42

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Title

Cytokine Responses in BALB/c Mice Immunized with Ovalbumin after Oral Administration of 5-Hydroxymethylfurfural

Author(s)

ALIZADEH M. | KHODAEI H. | Issue Writer Certificate

Keywords

5-hydroxymethylfurfuralQ1

cytokineQ1

ovalbuminQ1

Abstract

Introduction: 5-hydroxymethylfurfural (5-HMF) is one of the most important products of the Millard reaction. Several kinds of foods and beverages produce high amount of 5-HMF. In the recent years, many profitable effects of this compound have been demonstrated. Because of the role of T helper cells cytokines in the inflammatory responses, this study sought to investigate the effects of 5-HMF on IFN-γ and IL-4 levels respectively as Th1 and Th2 cytokines in BALB/c mice immunized with ovalbumin (OVA). Materials & methods: BALB/c mice (n=5 for each group) were grouped as follow: control, vehicle, and two different treatment groups. The treatment groups received daily doses of 188 and 750 mg/kg body weight, respectively. The groups were immunized with OVA on days 7 and 28 except for the control. Interleukin 4(IL-4) and interferon gamma (IFN-γ ) levels were measured in serum by ELISA. Findings: IL-4 levels were significantly suppressed in 5-HMF treatment groups (P<0. 001). IFN-γ levels were significantly lowered in the treatment groups (P<0. 05). Further, no significant difference was observed in IL-4 and IFN-γ levels between the treatment groups (P>0. 05). Discussion & conclusions: 5-HMF reduced production of selected components of Th1 and Th2 cytokine responses in immunized BALB/c mice.

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APA: Copy

ALIZADEH, M., & KHODAEI, H.. (2018). Cytokine Responses in BALB/c Mice Immunized with Ovalbumin after Oral Administration of 5-Hydroxymethylfurfural. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 26(1 ), 34-42. SID. https://sid.ir/paper/90451/en

Vancouver: Copy

ALIZADEH M., KHODAEI H.. Cytokine Responses in BALB/c Mice Immunized with Ovalbumin after Oral Administration of 5-Hydroxymethylfurfural. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;26(1 ):34-42. Available from: https://sid.ir/paper/90451/en

IEEE: Copy

M. ALIZADEH, and H. KHODAEI, “Cytokine Responses in BALB/c Mice Immunized with Ovalbumin after Oral Administration of 5-Hydroxymethylfurfural,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 1 , pp. 34–42, 2018, [Online]. Available: https://sid.ir/paper/90451/en

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