STUDY ON ASSOCIATION BETWEEN GSTP1 (RS1695) AND LATE-ONSET ALZHEIMER DISEASE AND INTERACTION WITH APOε4

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JAFARIAN ZAHRA; KOWSARI ALI; KAMALI KOUROSH; KHORRAM KHORSHID HAMID REZA

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Journal: Salmand: Iranian Journal of Ageing Year:2016 | Volume:11 | Issue:3 Page(s): 440-446

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Title

STUDY ON ASSOCIATION BETWEEN GSTP1 (RS1695) AND LATE-ONSET ALZHEIMER DISEASE AND INTERACTION WITH APOε4

Author(s)

JAFARIAN ZAHRA | KOWSARI ALI | KAMALI KOUROSH | KHORRAM KHORSHID HAMID REZA | Issue Writer Certificate

Keywords

ALZHEIMERQ2

POLYMORPHISMSQ1

LATE-ONSETQ2

FREE RADICALSQ2

Abstract

Objectives: GSTs are detoxification enzymes that remove excess reactive oxygen species (ROS) from cells. Evidence suggests that oxidative stress plays a role in several stages of the neurodegenarative disease like ALZHEIMER disease. FREE RADICALS and similar molecules are classified as reactive oxygen species (ROS), which can cause oxidative modifications in the cell. In this study we have investigated the association between GSTP1 (rs1695) and AD risk for genetic variant in Iranian population.Methods & Materials: The patient group consisted of 280 cases for GSTP1 gene investigation, whose ALZHEIMER disease had been approved by psychologists based on clinical test (DSM-IV). The control group included 168 healthy individuals, satisfying the condition of not having any psychological disorders. Individuals’ genotype have been determined by PCR-RFLP method. Statistical analysis was done by logistic regression using Open Epi 2.3.1 and SPSS 16.Results: Significant association was observed between heterozygote genotype (AG) rs1695 A/G of GSTP1 gene and the risk of ALZHEIMER disease (P=0.005, OR=0.57 [0.38-0.84]).This genotype acts as a protective factor. This observed result was significant in within women group (P=0.02). Significant interaction was also found between heterozygote genotype (AG) rs1695 A/G of GSTP1 gene (protective factor) and absentε4 allele in our study group (P=0.001).Conclusion: Based on our results, we suggest that heterozygote genotype (AG) rs1695 A/G of GSTP1 gene can act as a protective factor for ALZHEIMER disease in Iranian population.

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APA: Copy

JAFARIAN, ZAHRA, KOWSARI, ALI, KAMALI, KOUROSH, & KHORRAM KHORSHID, HAMID REZA. (2016). STUDY ON ASSOCIATION BETWEEN GSTP1 (RS1695) AND LATE-ONSET ALZHEIMER DISEASE AND INTERACTION WITH APOε4. IRANIAN JOURNAL OF AGEING, 11(3), 440-446. SID. https://sid.ir/paper/95131/en

Vancouver: Copy

JAFARIAN ZAHRA, KOWSARI ALI, KAMALI KOUROSH, KHORRAM KHORSHID HAMID REZA. STUDY ON ASSOCIATION BETWEEN GSTP1 (RS1695) AND LATE-ONSET ALZHEIMER DISEASE AND INTERACTION WITH APOε4. IRANIAN JOURNAL OF AGEING[Internet]. 2016;11(3):440-446. Available from: https://sid.ir/paper/95131/en

IEEE: Copy

ZAHRA JAFARIAN, ALI KOWSARI, KOUROSH KAMALI, and HAMID REZA KHORRAM KHORSHID, “STUDY ON ASSOCIATION BETWEEN GSTP1 (RS1695) AND LATE-ONSET ALZHEIMER DISEASE AND INTERACTION WITH APOε4,” IRANIAN JOURNAL OF AGEING, vol. 11, no. 3, pp. 440–446, 2016, [Online]. Available: https://sid.ir/paper/95131/en

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