Evaluation of the antidepressant-like effect of Viola odorata hydroalcoholic extract in male mice

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Shafei Zhivar; ABBASI MALEKI SAEID; GHADERI PAKDEL FIROUZ

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Journal: Journal of Birjand University of Medical Sciences Year:2019 | Volume:25 | Issue:4 Page(s): 286-296

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Title

Evaluation of the antidepressant-like effect of Viola odorata hydroalcoholic extract in male mice

Author(s)

Shafei Zhivar | ABBASI MALEKI SAEID | GHADERI PAKDEL FIROUZ | Issue Writer Certificate

Keywords

Viola Odorata ExtractQ1

DepressionQ2

Animal ModelsQ2

Abstract

Background and Aim: In traditional medicine Viola odorata (VO) has been used as anti-inflammatory, hypnotic, sedative, antioxidant, anti-anxiety, and therapist for neuropsychiatric disorders; Hence, in the present study, the antidepressant effect of VO hydroalcoholic extract in mice was investigated. Materials and Methods: In this experimental study, one hundred-fourteen male albino mice were randomly divided into normal saline or control (10ml/kg, i. p), fluoxetine (20mg/kg, i. p), imipramine (30mg/kg, i. p) and, VO extract (50, 100, 200, 400 mg/kg, i. p), respectively. The antidepressant-like activity was performed by behavioral tests as forced swimming test (FST), tail suspension test (TST), and open field test. Results: The VO extract (100 to 400 mg/kg) reduced immobility time in both FST and TST (P<0. 01 and P<0. 001, respectively). The extract increased swimming time (P<0. 01 and P<0. 001, respectively) without significant change of climbing time (P>0. 05). In OFT, doses of 200mg / kg and 400mg / kg of VO caused the reduced the number of crossings from the square and on the two feet (P <0. 05 and P <0. 01 respectively). Conclusion: Probably; the acute doses of the Viola odorata; Similar to fluoxetine; Are likely to cause antidepressant effects.

Cites

Antidepressant-like effect of Cuminum cyminum essential oil on the forced swim and tail suspension tests in male mice

References

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APA: Copy

Shafei, Zhivar, ABBASI MALEKI, SAEID, & GHADERI PAKDEL, FIROUZ. (2019). Evaluation of the antidepressant-like effect of Viola odorata hydroalcoholic extract in male mice. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, 25(4 ), 286-296. SID. https://sid.ir/paper/95642/en

Vancouver: Copy

Shafei Zhivar, ABBASI MALEKI SAEID, GHADERI PAKDEL FIROUZ. Evaluation of the antidepressant-like effect of Viola odorata hydroalcoholic extract in male mice. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;25(4 ):286-296. Available from: https://sid.ir/paper/95642/en

IEEE: Copy

Zhivar Shafei, SAEID ABBASI MALEKI, and FIROUZ GHADERI PAKDEL, “Evaluation of the antidepressant-like effect of Viola odorata hydroalcoholic extract in male mice,” JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 4 , pp. 286–296, 2019, [Online]. Available: https://sid.ir/paper/95642/en

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