EFFECT OF ORAL RIFAMPIN IN PROPHYLAXIS OF STAPHYLOCOCCUS AUROUS NASOCARRIERS OF HEMODIALYSIS PATIENTS

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ALAVI NAEINI R.; SANADGOL H.; FORGHANI B.A.M.; DARVISHI M.

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Journal: Annals of Military and Health Sciences Research Year:2007 | Volume:4 | Issue:4 (SERIAL NUMBER 16) Page(s): 1009-1015

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Title

EFFECT OF ORAL RIFAMPIN IN PROPHYLAXIS OF STAPHYLOCOCCUS AUROUS NASOCARRIERS OF HEMODIALYSIS PATIENTS

Author(s)

ALAVI NAEINI R. | SANADGOL H. | FORGHANI B.A.M. | DARVISHI M. | Issue Writer Certificate

Keywords

HEMODIALYSISQ3

NASOCARRIERQ3

RIFAMPINQ3

STAPHYLOCOCCUS AUROUSQ3

Abstract

Background: patients on HEMODIALYSIS exhibit higher susceptibility of infection because of decreased immunity. Several microbial pathogens are responsible for the variety of infections. STAPHYLOCOCCUS AUROUS is one of the most important bacterial agents that specially colonized the skin, nasal mucosa and pharynx. The nasal carriage rate is estimated to be about 42% to 60% in similar studies that is greater than then general population (20% - 40%). STAPHYLOCOCCUS AUROUS is one of the most important causes of shunt infection, exit site infection, bacteremia, septicemia, bone and joint infection in HEMODIALYSIS patients.Material and methods: We conducted a clinical trial before and after treatment in which culture specimens were collected from anterior nasal nares of HEMODIALYSIS patients and were cultured.Results: In a total of 74 patients, 35 cases were culture positive (47/3%). RIFAMPIN 300mg twice daily was prescribed for patient with positive culture for 5 days. In five month follow up, 21 cases had negative culture after 1 month and 19, 18, 16 and 14 specimens had negative culture for the further evaluation, respectively (90/4%, 85/7%, 76/1%, 66/6%).Conclusions: There was not a significance difference between the duration of HEMODIALYSIS and the colonization rate of STAPHYLOCOCCUS AUROUS (p>0.05).

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