Treating umbilical granuloma with topical corticosteroid: A systematic review and meta-analysis

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Sandinirwan Indra; Leo Henry; Hasanah Hasanah; Karina Permata Putri

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Journal Paper

Paper Information

Journal: JOURNAL OF RESEARCH IN CLINICAL MEDICINE Year:2021 | Volume:9 | Issue:1 Page(s): 0-0

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Title

Treating umbilical granuloma with topical corticosteroid: A systematic review and meta-analysis

Author(s)

Sandinirwan Indra | Leo Henry | Hasanah Hasanah | Karina Permata Putri | Issue Writer Certificate

Keywords

Discharge

Granuloma

Infants

Lump

Umbilicus

Abstract

Introduction: Umbilical Granuloma so far can be treated with surgery or with silver nitrate. In limited facilities, such as remote areas where the surgeons are limited, pharmacological therapy with silver nitrate or topical steroid can be administered. However, treatment with silver nitrate requires medical personnel and has unfavorable adverse effects if performed improperly. This review pointed to evaluate the effectiveness of topical steroids for treating umbilical Granulomas, compared to silver nitrate therapy. Method: The literature search was done in databases including PubMed, Embase, and Google Scholar. Literature selection was performed with limitations from 2000 to 2020 to ensure the novelty and limited to articles written in English with a target population of Infants younger than 6 months. To retrieve the articles, topical corticosteroids, topical steroids, and umbilical Granuloma were used as keywords. Results: The findings from the included studies show similar sample characteristics. The study conducted by Brodsgaard et al. had an older mean sample age than the study of Ogawa et al. (53. 4 vs. 31 days). The risk of topical steroid treatment failure on an individual study conducted by Brodsgaard et al. and Ogawa et al. was 3. 0 (95%CI: 0. 33– 27. 23) and 0. 94 (95%CI: 0. 40– 2. 21), respectively. Overall analysis, the risk of treatment failure was 1. 09 (95%CI: 0. 49– 2. 43), and there was no difference between the two interventions. Conclusions: One of the umbilical Granuloma treatment options that can be considered is topical steroids, such as clobetasol propionate 0. 05% or betamethasone valerate 0. 12%. Although topical steroids have a longer therapeutic healing time than silver nitrate, they benefit from a better safety profile. The non-inferiority study of topical steroids to silver nitrate has not been met yet.

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APA: Copy

Sandinirwan, Indra, Leo, Henry, Hasanah, Hasanah, & Karina, Permata Putri. (2021). Treating umbilical granuloma with topical corticosteroid: A systematic review and meta-analysis. JOURNAL OF RESEARCH IN CLINICAL MEDICINE, 9(1), 0-0. SID. https://sid.ir/paper/969153/en

Vancouver: Copy

Sandinirwan Indra, Leo Henry, Hasanah Hasanah, Karina Permata Putri. Treating umbilical granuloma with topical corticosteroid: A systematic review and meta-analysis. JOURNAL OF RESEARCH IN CLINICAL MEDICINE[Internet]. 2021;9(1):0-0. Available from: https://sid.ir/paper/969153/en

IEEE: Copy

Indra Sandinirwan, Henry Leo, Hasanah Hasanah, and Permata Putri Karina, “Treating umbilical granuloma with topical corticosteroid: A systematic review and meta-analysis,” JOURNAL OF RESEARCH IN CLINICAL MEDICINE, vol. 9, no. 1, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/969153/en

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