Paracrine Eﬀ ect of Synovial-Derived Stem Cells on Induced Knee Osteoarthritis in Rats

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TANIDEH NADER; Nabavizadeh Sara Sadat; ASHKANI ESFAHANI SOHEIL; KOOHI HOSSEINABADI OMID; GHAEMMAGHAMI PARVIN; Zare Shahrokh; AZARPIRA NEGAR; Tanideh Romina; DANESHI SAJAD

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Journal: SHIRAZ E-MEDICAL JOURNAL Year:2021 | Volume:22 | Issue:6 Page(s): 0-0

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Title

Paracrine Eﬀ ect of Synovial-Derived Stem Cells on Induced Knee Osteoarthritis in Rats

Author(s)

Keywords

Knee

Mesenchymal Stem Cells

Osteoarthritis

Paracrine Communication

Rats

Abstract

Background: Osteoarthritis (OA) is a progressive degenerative disease. Previous treatment strategies have tried to slow the progress of OA. Objectives: The present study aimed to stop and reverse the progressive nature of OA by the paracrine eﬀ ects of synovial stem cells. Methods: Fifty male Sprague Dawley rats were randomly allocated to ﬁ ve equal groups (n = 10). The control group received no treatment. The second group received an intra-articular Hyalgan injection. The third group received an intra-articular injection of secreta. The fourth group received an intra-articular injection of synovial-derived stem cells (5 10 ). The last group received an intra-articular injection of secreta combined with synovial-derived stem cells (5 10 6 ). Three months after treatment, the samples were harvested and evaluated by histopathological and radiological analyses. Results: Histopathological and radiological ﬁ ndings demonstrated signiﬁ cant diﬀ erences between the synovial stem cell combined with the secreta group and the control and Hyalgan groups. Signiﬁ cant diﬀ erences were observed in the subchondral bone and matrix scores between the secreta group and the synovial stem cell and Hyalgan groups (P-value = 0. 042 and P-value = 0. 0001, respectively). Both secreta and synovial stem cell groups showed better healing in terms of cell population viability index than the Hyalgan group (P-value = 0. 015 and P-value = 0. 005, respectively). The synovial stem cell combined with secreta group showed a signiﬁ cant diﬀ erence from the synovia stem cell group in both medial femoral condyle and fabella osteophyte indices (P-value = 0. 004 and P-value = 0. 011, respectively). Conclusions: The group treated with synovial stem cells combined with secreta showed better outcomes than other groups in histopathological and radiological evaluations.

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APA: Copy

TANIDEH, NADER, Nabavizadeh, Sara Sadat, ASHKANI ESFAHANI, SOHEIL, KOOHI HOSSEINABADI, OMID, GHAEMMAGHAMI, PARVIN, Zare, Shahrokh, AZARPIRA, NEGAR, Tanideh, Romina, & DANESHI, SAJAD. (2021). Paracrine Eﬀ ect of Synovial-Derived Stem Cells on Induced Knee Osteoarthritis in Rats. SHIRAZ E MEDICAL JOURNAL, 22(6), 0-0. SID. https://sid.ir/paper/969416/en

Vancouver: Copy

TANIDEH NADER, Nabavizadeh Sara Sadat, ASHKANI ESFAHANI SOHEIL, KOOHI HOSSEINABADI OMID, GHAEMMAGHAMI PARVIN, Zare Shahrokh, AZARPIRA NEGAR, Tanideh Romina, DANESHI SAJAD. Paracrine Eﬀ ect of Synovial-Derived Stem Cells on Induced Knee Osteoarthritis in Rats. SHIRAZ E MEDICAL JOURNAL[Internet]. 2021;22(6):0-0. Available from: https://sid.ir/paper/969416/en

IEEE: Copy

NADER TANIDEH, Sara Sadat Nabavizadeh, SOHEIL ASHKANI ESFAHANI, OMID KOOHI HOSSEINABADI, PARVIN GHAEMMAGHAMI, Shahrokh Zare, NEGAR AZARPIRA, Romina Tanideh, and SAJAD DANESHI, “Paracrine Eﬀ ect of Synovial-Derived Stem Cells on Induced Knee Osteoarthritis in Rats,” SHIRAZ E MEDICAL JOURNAL, vol. 22, no. 6, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/969416/en

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