Vogt-Koyanagi-Harada is a Curable Autoimmune Disease: Early Diagnosis and Immediate Dual Steroidal and Non-Steroidal Immunosuppression are Crucial Prerequisites

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Papasavvas Ioannis; TUGAL TUTKUN ILKNUR; Herbort Jr. Carl P.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF CURRENT OPHTHALMOLOGY Year:2020 | Volume:32 | Issue:4 Page(s): 310-314

Download Full-Text

View:

Download:

110

Cites:

Information Journal Paper

Title

Vogt-Koyanagi-Harada is a Curable Autoimmune Disease: Early Diagnosis and Immediate Dual Steroidal and Non-Steroidal Immunosuppression are Crucial Prerequisites

Author(s)

Papasavvas Ioannis | TUGAL TUTKUN ILKNUR | Herbort Jr. Carl P. | Issue Writer Certificate

Keywords

Chronic evolution

Dual immunosuppression

Sunset-glow fundus

Vogt-Koyanagi-Harada disease

Abstract

Purpose: It is crucial to subdivide Vogt– Koyanagi– Harada (VKH) disease into two subentities, initial-onset disease versus chronically evolving disease. For early diagnosis and precise follow‑ up of VKH choroiditis, the “ Revised criteria for VKH” are no more sufficient for the appraisal of VKH and new biomarkers for disease activity are needed. It has been shown that, if initial-onset disease is treated promptly within the “ therapeutic window of opportunity” and long enough with dual steroidal and non-steroidal immunosuppression, the disease can be cured in a large proportion of cases, an approach still contested. The proportion of chronic evolution and/or sunset-glow fundus (SGF) following steroidal monotherapy versus dual steroidal and non-steroidal immunosuppression was compared. Methods: A literature search was performed, identifying studies on initial-onset VKH treated either by steroidal monotherapy or dual immunosuppression. Evolution toward chronicity and/or SGF was compared in both groups. Results: Twenty studies were identified with reported long‑ term outcomes. In 16 studies, 802 patients received steroidal monotherapy, while in 4 studies, 172 patients received dual steroidal and non-steroidal immunosuppression. Chronic evolution and SGF occurred, respectively, in 44% and 59% in the corticosteroid‑ alone group versus 2. 3% and 17. 5% in the dual therapy group with no chronic evolution in three studies and no SGF in two studies. Conclusions: Chronic evolution and SGF are significantly less frequent in initial‑ onset VKH when treated with immediate dual steroidal and non-steroidal immunosuppression with a high proportion of healed cases. This combined approach seems recommended in the management of initial-onset VKH disease.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

APA: Copy

Papasavvas, Ioannis, TUGAL TUTKUN, ILKNUR, & Herbort Jr., Carl P.. (2020). Vogt-Koyanagi-Harada is a Curable Autoimmune Disease: Early Diagnosis and Immediate Dual Steroidal and Non-Steroidal Immunosuppression are Crucial Prerequisites. JOURNAL OF CURRENT OPHTHALMOLOGY, 32(4), 310-314. SID. https://sid.ir/paper/979138/en

Vancouver: Copy

Papasavvas Ioannis, TUGAL TUTKUN ILKNUR, Herbort Jr. Carl P.. Vogt-Koyanagi-Harada is a Curable Autoimmune Disease: Early Diagnosis and Immediate Dual Steroidal and Non-Steroidal Immunosuppression are Crucial Prerequisites. JOURNAL OF CURRENT OPHTHALMOLOGY[Internet]. 2020;32(4):310-314. Available from: https://sid.ir/paper/979138/en

IEEE: Copy

Ioannis Papasavvas, ILKNUR TUGAL TUTKUN, and Carl P. Herbort Jr., “Vogt-Koyanagi-Harada is a Curable Autoimmune Disease: Early Diagnosis and Immediate Dual Steroidal and Non-Steroidal Immunosuppression are Crucial Prerequisites,” JOURNAL OF CURRENT OPHTHALMOLOGY, vol. 32, no. 4, pp. 310–314, 2020, [Online]. Available: https://sid.ir/paper/979138/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops