Phenotypic and genotypic evaluation of fluoroquinolones resistance in Klebsiella pneumoniae isolates from urinary tract infections in Bojnourd city

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Amiri Mohadeseh; Jamshidian Mojaver Majid; FARZIN Hamidreza

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Journal Paper

Paper Information

Journal: Medical Journal of Mashhad University of Medical Sciences Year:2020 | Volume:63 | Issue:3 Page(s): 2335-2340

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Information Journal Paper

Title

Phenotypic and genotypic evaluation of fluoroquinolones resistance in Klebsiella pneumoniae isolates from urinary tract infections in Bojnourd city

Author(s)

Amiri Mohadeseh | Jamshidian Mojaver Majid | FARZIN Hamidreza | Issue Writer Certificate

Keywords

UTI

Klebsiella pneumonia

Antibiotic resistance

Fluoroquinolonese

Abstract

Introduction: Urinary tract infection (UTI) is one of the most common bacterial infections, accounting for a significant proportion of hospital clients (about 30-40%). The emergence of resistance to cephalosporins, fluoroquinolones and trimethoprim-sulfamethoxazole which were often used to treat general and nosocomial infections, delayed effective treatment of these diseases and subsequently resulted in increased infections and mortality of patients. Methods: In this study, 30 specimens of positive cultures of urinary tract infection which were referred to Imam Reza Hospital laboratory in Bojnourd were studied. The resistance and susceptibility of the isolates were determined by disc diffusion method. The presence of QnrA gen was assessed by molecular methods with specific primers. Results: The phenotypic resistance of isolates to nalidixic acid, levofloxacin and ciprofloxacin were 43. 33%, 26. 66% and 40%, respectively. Also, genotypic analysis of the isolates showed 6. 66% of the studied genes. Conclusion: Based on the results of the present study, it can be said that resistance to antibiotics belonging to the fluoroquinolones is not yet widely high.

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APA: Copy

Amiri, Mohadeseh, Jamshidian Mojaver, Majid, & FARZIN, Hamidreza. (2020). Phenotypic and genotypic evaluation of fluoroquinolones resistance in Klebsiella pneumoniae isolates from urinary tract infections in Bojnourd city. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 63(3 ), 2335-2340. SID. https://sid.ir/paper/979557/en

Vancouver: Copy

Amiri Mohadeseh, Jamshidian Mojaver Majid, FARZIN Hamidreza. Phenotypic and genotypic evaluation of fluoroquinolones resistance in Klebsiella pneumoniae isolates from urinary tract infections in Bojnourd city. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;63(3 ):2335-2340. Available from: https://sid.ir/paper/979557/en

IEEE: Copy

Mohadeseh Amiri, Majid Jamshidian Mojaver, and Hamidreza FARZIN, “Phenotypic and genotypic evaluation of fluoroquinolones resistance in Klebsiella pneumoniae isolates from urinary tract infections in Bojnourd city,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 63, no. 3 , pp. 2335–2340, 2020, [Online]. Available: https://sid.ir/paper/979557/en

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