In vitro antifungal susceptibility pattern of Candida species isolated from gastroesophageal candidiasis

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Mirshekar Mohsen; EMAMI MOHAMMAD HASSAN; MOHAMMADI RASOUL

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Journal Paper

Paper Information

Journal: GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH Year:2021 | Volume:14 | Issue:3 Page(s): 260-266

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Title

In vitro antifungal susceptibility pattern of Candida species isolated from gastroesophageal candidiasis

Author(s)

Mirshekar Mohsen | EMAMI MOHAMMAD HASSAN | MOHAMMADI RASOUL | Issue Writer Certificate

Keywords

antifungal susceptibility testing

Candida spp.

gastroesophageal

Abstract

Aim: The current study aimed to determine the antifungal susceptibility profile of Candida species isolated from gastroesophageal lesions Background: Gastroesophageal candidiasis is a common infection among HIV/AIDS patients and those who are taking PPI and H2RAs drugs. More than 20 Candida spp. can cause different types of mucocutaneous infections in humans. The present study was conducted to assess the antifungal susceptibility testing of clinical Candida spp. isolated from gastroesophageal lesions. Methods: Forty-eight clinical samples were collected from 60 patients undergoing endoscopy. All isolates were identified by molecular techniques (PCR-RFLP). The profiles of the susceptibility of Candida spp. to seven antifungal agents, i. e. amphotericin B, fluconazole, itraconazole, luliconazole, voriconazole, posaconazole, and caspofungin, were evaluated using broth microdilution. Results: The susceptibility profile of Candida isolates revealed 100% sensitivity to amphotericin B, caspofungin, and voriconazole. Moreover, fluconazole-(6. 5%) and itraconazole-resistant (2. 1%) isolates were observed. Conclusion: With regard to the increase in fluconazole-resistant Candida species, it is necessary to determine the in vitro antifungal susceptibility pattern of clinical isolates for the best management of infection and to prevent the emergence of drug resistant isolates.

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APA: Copy

Mirshekar, Mohsen, EMAMI, MOHAMMAD HASSAN, & MOHAMMADI, RASOUL. (2021). In vitro antifungal susceptibility pattern of Candida species isolated from gastroesophageal candidiasis. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 14(3), 260-266. SID. https://sid.ir/paper/980153/en

Vancouver: Copy

Mirshekar Mohsen, EMAMI MOHAMMAD HASSAN, MOHAMMADI RASOUL. In vitro antifungal susceptibility pattern of Candida species isolated from gastroesophageal candidiasis. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2021;14(3):260-266. Available from: https://sid.ir/paper/980153/en

IEEE: Copy

Mohsen Mirshekar, MOHAMMAD HASSAN EMAMI, and RASOUL MOHAMMADI, “In vitro antifungal susceptibility pattern of Candida species isolated from gastroesophageal candidiasis,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 14, no. 3, pp. 260–266, 2021, [Online]. Available: https://sid.ir/paper/980153/en

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