ASSOCIATION OF ADIPONECTIN GENE (RS 2241766) POLYMORPHISM AND COLORECTAL CANCER IN TEHRAN, IRAN

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SAFAEI AKRAM; KARIMI KHATOON; ARKANI MARAL; ROSTAMI FATEMEH; ARBABI ELHAM; VAHEDI MOHSEN; MOHEBI SEYED REZA; VAFAIE MOHAMMAD; FATEMI SEYED REZA; ZALI MOHAMMAD REZD

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Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2012 | Volume:22 | Issue:2 Page(s): 110-115

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Title

ASSOCIATION OF ADIPONECTIN GENE (RS 2241766) POLYMORPHISM AND COLORECTAL CANCER IN TEHRAN, IRAN

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Keywords

COLORECTAL CANCERQ2

AIPONECTIN GENEQ2

PCR–RFLPQ2

COLORECTAL CANCERQ2

Abstract

Background: Many studies have been shown association between low level of Adiponectin hormone and insulin resistancy, obesity and increased risk of COLORECTAL CANCER. The goal of this study was to evaluate prevalence of polymorphism of Adiponectin gene rs 2241766 in Tehran, Iran and to check the role of this polymorphism in increased risk of COLORECTAL CANCER.Materials and Methods: In this case- control study, genotyping of the Insulin gene were determined in 107 COLORECTAL CANCER patients and 107controls by using polymerase chain reaction and restriction fragment length polymorphism genotyping assays (PCR-RFLP).The statistical analysis was done using SPSS ver.16.Results: Polymorphism of Adiponectin rs 2241766 was not a predisposing factor to increased risk of CRC (p=0.29). The genotype GT compared with TT, was not associated with increased risk of CRC (OR=1.02, CI=0.52-1.97; p=0.95), but GG versus TT (OR=0.015, CI=0.29-0.78; p=0.025) was associated with decreased risk of CRC. Frequency of mutant allele hadn' t significant difference between patients and controls (OR=7.34, 95% CI=0.45-1.19; p=0.21).Conclusion: These findings suggest that polymorphism of adiponectin rs 2241766 isn' t associated with increased risk of CRC.

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APA: Copy

SAFAEI, AKRAM, KARIMI, KHATOON, ARKANI, MARAL, ROSTAMI, FATEMEH, ARBABI, ELHAM, VAHEDI, MOHSEN, MOHEBI, SEYED REZA, VAFAIE, MOHAMMAD, FATEMI, SEYED REZA, & ZALI, MOHAMMAD REZD. (2012). ASSOCIATION OF ADIPONECTIN GENE (RS 2241766) POLYMORPHISM AND COLORECTAL CANCER IN TEHRAN, IRAN. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 22(2), 110-115. SID. https://sid.ir/paper/98715/en

Vancouver: Copy

SAFAEI AKRAM, KARIMI KHATOON, ARKANI MARAL, ROSTAMI FATEMEH, ARBABI ELHAM, VAHEDI MOHSEN, MOHEBI SEYED REZA, VAFAIE MOHAMMAD, FATEMI SEYED REZA, ZALI MOHAMMAD REZD. ASSOCIATION OF ADIPONECTIN GENE (RS 2241766) POLYMORPHISM AND COLORECTAL CANCER IN TEHRAN, IRAN. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2012;22(2):110-115. Available from: https://sid.ir/paper/98715/en

IEEE: Copy

AKRAM SAFAEI, KHATOON KARIMI, MARAL ARKANI, FATEMEH ROSTAMI, ELHAM ARBABI, MOHSEN VAHEDI, SEYED REZA MOHEBI, MOHAMMAD VAFAIE, SEYED REZA FATEMI, and MOHAMMAD REZD ZALI, “ASSOCIATION OF ADIPONECTIN GENE (RS 2241766) POLYMORPHISM AND COLORECTAL CANCER IN TEHRAN, IRAN,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 22, no. 2, pp. 110–115, 2012, [Online]. Available: https://sid.ir/paper/98715/en

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