EFFECT OF GRAPE SEED EXTRACT ON CARDIOMYOCYTE APOPTOSIS IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

DOUSTAR YOUSEF; MOHAJERI DARYOUSH; REZAEI ALI

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2011 | Volume:21 | Issue:3 (65) Page(s): 168-174

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,114

Download:

Cites:

Information Journal Paper

Title

EFFECT OF GRAPE SEED EXTRACT ON CARDIOMYOCYTE APOPTOSIS IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Author(s)

DOUSTAR YOUSEF | MOHAJERI DARYOUSH | REZAEI ALI | Issue Writer Certificate

Keywords

APOPTOSISQ1

GRAPE SEEDQ2

DIABETESQ2

RATQ2

Abstract

Background: APOPTOSIS is a regulated, energy-dependent, cell suicide mechanism that has also been reported to play a critical role in the development of diabetic cardiomyopathy. In the present study, the effect of GRAPE SEED extract on cardiomyocyte APOPTOSIS status in streptozotocin induced diabetic RATs was investigated.Materials and methods: 40 male wistar RATs with age of 12 weeks and 200-300g weight were randomly allocated into four equal groups namely normal vehicle treated RATs, healthy RATs received 40 mg/kg GRAPE SEED extract, diabetic RATs and diabetic RATs treated with GRAPE SEED extract (40 mg/kg) for 12 weeks. DIABETES was induced by a single intraperitoneal injection of STZ (50 mg/kg) in diabetic groups.Results: Significant increase of apoptotic cells was noted in diabetic RATs. Oral administration of GRAPE SEED extract resulted in significant reduction of cardiomyocyte APOPTOSIS in diabetic RATs.Conclusion: These results provide confirmatory evidence of APOPTOSIS in DIABETES and point towards the possible anti-apoptotic effect of GRAPE SEED extract.

Cites

No record.

References

No record.

Cite

APA: Copy

DOUSTAR, YOUSEF, MOHAJERI, DARYOUSH, & REZAEI, ALI. (2011). EFFECT OF GRAPE SEED EXTRACT ON CARDIOMYOCYTE APOPTOSIS IN STREPTOZOTOCIN INDUCED DIABETIC RATS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 21(3 (65)), 168-174. SID. https://sid.ir/paper/98511/en

Vancouver: Copy

DOUSTAR YOUSEF, MOHAJERI DARYOUSH, REZAEI ALI. EFFECT OF GRAPE SEED EXTRACT ON CARDIOMYOCYTE APOPTOSIS IN STREPTOZOTOCIN INDUCED DIABETIC RATS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2011;21(3 (65)):168-174. Available from: https://sid.ir/paper/98511/en

IEEE: Copy

YOUSEF DOUSTAR, DARYOUSH MOHAJERI, and ALI REZAEI, “EFFECT OF GRAPE SEED EXTRACT ON CARDIOMYOCYTE APOPTOSIS IN STREPTOZOTOCIN INDUCED DIABETIC RATS,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 21, no. 3 (65), pp. 168–174, 2011, [Online]. Available: https://sid.ir/paper/98511/en

Related Journal Papers