THE PROTECTIVE EFFECT OF ETHANOL EXTRACT OF GINGER (ZINGIBER ‎OFFICINALE) ON SPERMATOGENESIS TOXICITY INDUCED BY DOXORUBICIN‎

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JUOIBAR FATEMEH; MOKHTARI MOKHTAR; DIANATPOUR MAHDI; SHARIATIE MEHRDAD

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Journal: Medical Sciences Journal of Islamic Azad University,Tehran Medical Branch Year:2017 | Volume:27 | Issue:2 Page(s): 88-96

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Title

THE PROTECTIVE EFFECT OF ETHANOL EXTRACT OF GINGER (ZINGIBER ‎OFFICINALE) ON SPERMATOGENESIS TOXICITY INDUCED BY DOXORUBICIN‎

Author(s)

JUOIBAR FATEMEH | MOKHTARI MOKHTAR | DIANATPOUR MAHDI | SHARIATIE MEHRDAD | Issue Writer Certificate

Keywords

GINGERQ2

DOXORUBICINQ1

BODY WEIGHTQ2

TESTESQ2

SPERM PARAMETERSQ1

RATQ2

Abstract

Background: DOX is one of the most common drugs used to treat different types of cancer, including ‎testicular cancer. The aim of this study was to evaluate the effect of ethanol extract of GINGER on ‎spermatogenesis in RATs.Materials and methods: In this experimental study, 56 male RATs Wistar were randomly divided into 6 ‎groups of 8 animals control, the sham and experimental group 1 receiving DOXORUBICIN (mg/kg.bw 3) ‎experimental 2 and 3 receiving GINGER extract (500 , 1000 mg/ kg. bw ) and experimental 4 and 5 ‎received a GINGER extract (500 , 1000 mg/ kg. bw ) + DOXORUBICIN. The RATs were fed extract daily, one ‎hour after DOXORUBICIN injection, for four weeks. DOX (3mg/kg) was administered once a week ‎intraperitoneally. Some SPERM PARAMETERS, such as the number, viability, morphology and mobility were ‎examined using Eosin-Ngrozin staining.Results: A significant decrease in BODY WEIGHT, sperm count, sperm motility, viability was observed in ‎drug-DOX-treated RATs compared with the control group. The reduction in the group treated with DOX ‎with GINGER 500 and 1000 mg/ kg significantly was offset compared with DOX.Conclusion: GINGER is able to have protective effect on SPERM PARAMETERS in adult male RAT induced by ‎Doxorobicin.‎

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APA: Copy

JUOIBAR, FATEMEH, MOKHTARI, MOKHTAR, DIANATPOUR, MAHDI, & SHARIATIE, MEHRDAD. (2017). THE PROTECTIVE EFFECT OF ETHANOL EXTRACT OF GINGER (ZINGIBER ‎OFFICINALE) ON SPERMATOGENESIS TOXICITY INDUCED BY DOXORUBICIN‎. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 27(2), 88-96. SID. https://sid.ir/paper/98582/en

Vancouver: Copy

JUOIBAR FATEMEH, MOKHTARI MOKHTAR, DIANATPOUR MAHDI, SHARIATIE MEHRDAD. THE PROTECTIVE EFFECT OF ETHANOL EXTRACT OF GINGER (ZINGIBER ‎OFFICINALE) ON SPERMATOGENESIS TOXICITY INDUCED BY DOXORUBICIN‎. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2017;27(2):88-96. Available from: https://sid.ir/paper/98582/en

IEEE: Copy

FATEMEH JUOIBAR, MOKHTAR MOKHTARI, MAHDI DIANATPOUR, and MEHRDAD SHARIATIE, “THE PROTECTIVE EFFECT OF ETHANOL EXTRACT OF GINGER (ZINGIBER ‎OFFICINALE) ON SPERMATOGENESIS TOXICITY INDUCED BY DOXORUBICIN‎,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 27, no. 2, pp. 88–96, 2017, [Online]. Available: https://sid.ir/paper/98582/en

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