EFFECT OF NANO ZINC OXIDE ON THE FORE LIMB BUD OF NMRI MOUSE EMBRYOS IN VIVO

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PARIVAR KAZEM; HAYATI ROODBARI NASRIN; BADIEI ALIREZA; NEJADFAZEL MARYAM

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Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2013 | Volume:23 | Issue:3 Page(s): 161-167

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Title

EFFECT OF NANO ZINC OXIDE ON THE FORE LIMB BUD OF NMRI MOUSE EMBRYOS IN VIVO

Author(s)

PARIVAR KAZEM | HAYATI ROODBARI NASRIN | BADIEI ALIREZA | NEJADFAZEL MARYAM | Issue Writer Certificate

Keywords

NANO ZINC OXIDEQ2

FORE LIMB BUD DEVELOPMENTQ2

IN VIVO TECHNIQUEQ2

Abstract

Background: Nanomaterials include components from 10 to 100 nanometer or even smaller in their size that can transport easily through the skin, lung alveoli or placenta. This research evaluated the effects of NANO ZINC OXIDE on limb bud development in fetal mice.Materials and Methods: In this experimental study, IN VIVO TECHNIQUE was used. Experimental goups of pregnant mice on day 11 of pregnancy were injected once intraperitoneally NANO ZINC OXIDE in doses of 0.5g/kg, 1g/kg and 1.5g/kg. On day 15 of pregnancy, the fetuses were brought out and the fore limb buds were separated from their bodies. The number of mesenchymal cells, cartilage, atrophy, and muscle, hypertrophy, dividing, degenerated cells, bone and red blood cells were analyzed in three regions from hand including fingers, forearm and arm by morphological, histological and statistical analysis.Results: Experimental fetus received 0.5g/kg NANO ZINC OXIDE were aborted. Cell counts in all three regions in experimental group2 (that received 1g/kg) and group3 (received 1.5g/kg of NANO ZINC OXIDE) showed significant changes in the number of mentioned cells in experimental goups 2 and 3, compared with control and sham (P<0.05, P<0.01, P< 0.001).Conclusion: Intraperitoneally injection of NANO ZINC OXIDE to pregnant mice showed significant effect on fore limb buds development in mice fetus.

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APA: Copy

PARIVAR, KAZEM, HAYATI ROODBARI, NASRIN, BADIEI, ALIREZA, & NEJADFAZEL, MARYAM. (2013). EFFECT OF NANO ZINC OXIDE ON THE FORE LIMB BUD OF NMRI MOUSE EMBRYOS IN VIVO. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 23(3), 161-167. SID. https://sid.ir/paper/98598/en

Vancouver: Copy

PARIVAR KAZEM, HAYATI ROODBARI NASRIN, BADIEI ALIREZA, NEJADFAZEL MARYAM. EFFECT OF NANO ZINC OXIDE ON THE FORE LIMB BUD OF NMRI MOUSE EMBRYOS IN VIVO. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2013;23(3):161-167. Available from: https://sid.ir/paper/98598/en

IEEE: Copy

KAZEM PARIVAR, NASRIN HAYATI ROODBARI, ALIREZA BADIEI, and MARYAM NEJADFAZEL, “EFFECT OF NANO ZINC OXIDE ON THE FORE LIMB BUD OF NMRI MOUSE EMBRYOS IN VIVO,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 23, no. 3, pp. 161–167, 2013, [Online]. Available: https://sid.ir/paper/98598/en

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