PROTECTIVE EFFECT OF L-CARNITINE AND GALLIC ACID IN RAT MODEL OF RENAL ISCHEMIA/REPERFUSION INJURY

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SADRI SARA; EDALATMANESH MOHAMMAD AMIN

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Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2017 | Volume:27 | Issue:3 Page(s): 164-170

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Title

PROTECTIVE EFFECT OF L-CARNITINE AND GALLIC ACID IN RAT MODEL OF RENAL ISCHEMIA/REPERFUSION INJURY

Author(s)

SADRI SARA | EDALATMANESH MOHAMMAD AMIN | Issue Writer Certificate

Keywords

NEPHRECTOMYQ1

ISCHEMIA/REPERFUSIONQ1

L-CARNITINEQ2

GALLIC ACIDQ2

RATQ2

Abstract

Background: Acute kidney injury (AKI) often occurs as a result of ischemia-reperfusion. AKI is a major renal disease associated with high mortality RATe. We investigated the renal protective effects of GALLIC ACID and L-CARNITINE on the blood factors in RAT model of renal ischemia-reperfusion. Materials and methods: In this experimental study, forty male Wistar RATs were randomly divided into 4 groups: controls, ISCHEMIA/REPERFUSION group (I/R), ischemia-reperfusion+L-carnitine (I/R+Lc, 500mg/kg), and ISCHEMIA/REPERFUSION + GALLIC ACID (I/R+GA, 100mg/kg). Animals of the experimental groups were subjected to unilateral NEPHRECTOMY and received GALLIC ACID and L-CARNITINE for 14 days. Then, ischemia was induced by clamping the renal pedicle for 45 minutes. 72 h later, they were sacrificed, and the blood level of BUN, uric acid and creatinine were analyzed. Results: The results showed a significant increase in BUN and creatinine of I/R group compared to the controls. Also, BUN and creatinine were significantly decreased in I/R+Lc and I/R+GA groups in comparison with I/R group. On other hand, blood level of uric acid was decreased in I/R+GA group compared to I/R group. Conclusion: The results indicated that ISCHEMIA/REPERFUSION induced acute renal injury in RAT model, and pretreatment with L-CARNITINE and GALLIC ACID can prevent the kidney tissue damage from renal ischemia.

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APA: Copy

SADRI, SARA, & EDALATMANESH, MOHAMMAD AMIN. (2017). PROTECTIVE EFFECT OF L-CARNITINE AND GALLIC ACID IN RAT MODEL OF RENAL ISCHEMIA/REPERFUSION INJURY. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 27(3), 164-170. SID. https://sid.ir/paper/98646/en

Vancouver: Copy

SADRI SARA, EDALATMANESH MOHAMMAD AMIN. PROTECTIVE EFFECT OF L-CARNITINE AND GALLIC ACID IN RAT MODEL OF RENAL ISCHEMIA/REPERFUSION INJURY. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2017;27(3):164-170. Available from: https://sid.ir/paper/98646/en

IEEE: Copy

SARA SADRI, and MOHAMMAD AMIN EDALATMANESH, “PROTECTIVE EFFECT OF L-CARNITINE AND GALLIC ACID IN RAT MODEL OF RENAL ISCHEMIA/REPERFUSION INJURY,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 27, no. 3, pp. 164–170, 2017, [Online]. Available: https://sid.ir/paper/98646/en

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