The effects of ubiquinone antioxidants on the MCL1 gene in the CA1 pyramidal cells of hippocampus of male Wistar rat following transient reperfusion inclusive ischemia

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Shirvani Shahenayati Maryam; ENTEZARI MALIHEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2019 | Volume:28 | Issue:4 Page(s): 270-276

Download Full-Text

Persian Verion

View:

394

Download:

Cites:

Information Journal Paper

Title

The effects of ubiquinone antioxidants on the MCL1 gene in the CA1 pyramidal cells of hippocampus of male Wistar rat following transient reperfusion inclusive ischemia

Author(s)

Shirvani Shahenayati Maryam | ENTEZARI MALIHEH | Issue Writer Certificate

Keywords

CoQ10Q2

Cerebral ischemiaQ1

Oxidative stressQ2

Free radicalsQ2

ApoptosisQ2

HippocampusQ2

Real time PCRQ2

Abstract

Background: The aim of this study was to evaluate effect of ubiquinone on MCL1 gene expression in hippocampal CA1 pyramidal cells following transient global ischemia/reperfusion in male Wistar rat. Materials and methods: In this study, we randomly selected 24 Wistar rats under 250-300 g weights that divided into 4 groups including group of observance (maintenance in the laboratory standard condition), ischemia to close the carotid artery and ischemia for 20 minutes, experiment to obtain CoQ10 dose and again obtain CoQ10 coenzyme, and group of control to obtain CoQ10 coenzyme solvent and ischemia again to obtain CoQ10 coenzyme solvent. CoQ10 coenzyme was injected via intraperitoneal (IP) method. The separated Hippocampus from the brain was studied by expressing the changes of MCL1 gene. Results: The expression of MCL1 anti-apoptic gene in observance group has been decreased compared to experiment group. There were not significant differences in the expression of MCL1 gene in the ischemia group towards control group. The expression of MCL1 gene have no significant differences in the coenzyme of control group towards observance group. Conclusion: According to the results, CoQ10 can create the protective effects in the severity of lesions of Hippocampus after ischemia and also increases the rate of the expression gene.

Cites

No record.

References

No record.

Cite

APA: Copy

Shirvani Shahenayati, Maryam, & ENTEZARI, MALIHEH. (2019). The effects of ubiquinone antioxidants on the MCL1 gene in the CA1 pyramidal cells of hippocampus of male Wistar rat following transient reperfusion inclusive ischemia. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 28(4 ), 270-276. SID. https://sid.ir/paper/98776/en

Vancouver: Copy

Shirvani Shahenayati Maryam, ENTEZARI MALIHEH. The effects of ubiquinone antioxidants on the MCL1 gene in the CA1 pyramidal cells of hippocampus of male Wistar rat following transient reperfusion inclusive ischemia. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2019;28(4 ):270-276. Available from: https://sid.ir/paper/98776/en

IEEE: Copy

Maryam Shirvani Shahenayati, and MALIHEH ENTEZARI, “The effects of ubiquinone antioxidants on the MCL1 gene in the CA1 pyramidal cells of hippocampus of male Wistar rat following transient reperfusion inclusive ischemia,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 28, no. 4 , pp. 270–276, 2019, [Online]. Available: https://sid.ir/paper/98776/en

Related Journal Papers