ATTENUATING EFFECTS OF AQUEOUS EXTRACT OF LAVANDULA ANGUSTIFOLIA ON ALZHEIMERIC RAT’S SPATIAL LEARNING

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SOHEILI KASHANI MASOUD; SALAMI MAHMOUD; TALAEI ZAVAREH SAYYED ALIREZA; HASHEMI MEHRDAD; MOTAGHI MONIKA; REZAEI TAVIRANI MOSTAFA

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Journal: Medical Sciences Journal of Islamic Azad University,Tehran Medical Branch Year:2011 | Volume:20 | Issue:4 Page(s): 221-227

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Title

ATTENUATING EFFECTS OF AQUEOUS EXTRACT OF LAVANDULA ANGUSTIFOLIA ON ALZHEIMERIC RAT’S SPATIAL LEARNING

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Keywords

ALZHEIMERQ2

LAVENDERQ2

SPATIAL LEARNINGQ2

MORRIS WATER MAZEQ2

RATQ2

Abstract

Background: ALZHEIMER is a progressive demential disease with destruction of brain neurons and severe deficiency of memory. For many years, plenty efforts was devoted to find an appropriate and efficient way for treatment of the disease. The present study was designed to assess if the herbal medicine Lavandula Angustifolia shares the MORRIS WATER MAZE training in improvement of learning behavior of the ALZHEIMERic RATs.Materials and methods: This experimental study was carried out on 40 wistar male RATs randomly divided in 4 groups: Two control groups (CO and ALZ) received 1 ml normal saline, and the other 2 groups (CO+E and ALZ+E) received 1000 mg/kg body weight LAVENDER extract, intra-peritoenally. To assess SPATIAL LEARNING of the animals, they were introduced to the MORRIS WATER MAZE to locate a fixed hidden platform. Probe test was applied to evaluate the memory consolidation. The time elapsed and distances passed in the correct quadrant were analyzed by ANCOVA test.Results: The CO group spent less time and distance to find the hidden platform than ALZ group. Also, CO+E and ALZ+E compared to CO and ALZ expended more time and distance to find platform. There was no difference between groups in probe trial test.Conclusion: The behavioral training positively influenced the maze learning in the ALZHEIMERic subjects. LAVENDER extract with dose of 1000 mg/kg is effective on improvement of the ALZHEIMER's disease.

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APA: Copy

SOHEILI KASHANI, MASOUD, SALAMI, MAHMOUD, TALAEI ZAVAREH, SAYYED ALIREZA, HASHEMI, MEHRDAD, MOTAGHI, MONIKA, & REZAEI TAVIRANI, MOSTAFA. (2011). ATTENUATING EFFECTS OF AQUEOUS EXTRACT OF LAVANDULA ANGUSTIFOLIA ON ALZHEIMERIC RAT’S SPATIAL LEARNING. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 20(4), 221-227. SID. https://sid.ir/paper/98686/en

Vancouver: Copy

SOHEILI KASHANI MASOUD, SALAMI MAHMOUD, TALAEI ZAVAREH SAYYED ALIREZA, HASHEMI MEHRDAD, MOTAGHI MONIKA, REZAEI TAVIRANI MOSTAFA. ATTENUATING EFFECTS OF AQUEOUS EXTRACT OF LAVANDULA ANGUSTIFOLIA ON ALZHEIMERIC RAT’S SPATIAL LEARNING. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2011;20(4):221-227. Available from: https://sid.ir/paper/98686/en

IEEE: Copy

MASOUD SOHEILI KASHANI, MAHMOUD SALAMI, SAYYED ALIREZA TALAEI ZAVAREH, MEHRDAD HASHEMI, MONIKA MOTAGHI, and MOSTAFA REZAEI TAVIRANI, “ATTENUATING EFFECTS OF AQUEOUS EXTRACT OF LAVANDULA ANGUSTIFOLIA ON ALZHEIMERIC RAT’S SPATIAL LEARNING,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 20, no. 4, pp. 221–227, 2011, [Online]. Available: https://sid.ir/paper/98686/en

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