Introduction: low back pain is the most common musculoskeletal complication. Although there are many ways to mange low back pain, achieving a concise, simple, and compact method is required in today's industrial societies. The purpose of this study was to evaluate the effect of six weeks selected core stabilization exercises on pain and functional disability in patients with non-specific chronic low back pain.Materials and methods: Twenty patients with non-specific chronic low back pain (10 men, 10 women, Mean+/-SD age; 24.55+/-3.4, height+/-SD; 164.15+/-9.6, weight+/-SD; 65.25+/-5.04) underwent a six week selected core stabilization exercises supervised by qualified physiotherapist. The amount of pain and functional disability were respectively measured using visual analogue scale (VAS) and Oswestry disability index (ODI) questionnaire both before and after the six-week exercise program. Data normality and the rate of intergroup changes were respectively calculated using Shapiro-Wilk Test and dependent student t-test (p<0.05). Also, data were analyzed by SPSS software, version 21.Results: Our finding showed that, after six-week exercise program, the amount of pain in participants with non-specific chronic low back pain was significantly reduced from 7.12±2.13 to 3.75±2.67 (p=0.00). Also, according to the results obtained from ODI questionnaire, after the six-week exercise intervention, the rate of functional disability was ameliorated significantly as it was reduced from 40.8±15.42 to 23.3±14.52 (p=0.00).Conclusion: Based on current results, the researcher's selected core stabilization exercises by reducing time of each training session, could have a significant role in rehabilitation of subjects with chronic low back pain. Therefore, this protocol can be used as a substitute for voluminous and time-consuming exercises.