tehran Province, containing majority of scientists and researchers, plays a significant role in the development of science and technology in the country. Obviously, this number of scientific potential to flourish needs facilities and infrastructures. One of the most important factors in development of knowledge-based businesses is proportionate physical context of firms.Moreover, proximity of knowledge-based companies to the universities, higher education institutes and industries leads to accelerating transforming knowledge into industrial process.Thus, Tehran Province requires more technology parks and towns than the past, to retain the benefit of its whole scientific potentials. In connection with this, at first, we recognized and ranked effective factors on locating Knowledge-Based Town, then used AHP to give weight to criteria and sub-criteria. In the next step, we applied these weights in GIS software and provided maps which are related to each, in the ARCmap. Then, we identified zoned map of the areas via GIS and overlapped the effective factors on locating town of knowledge, with two priorities in the province, and the result indicated that the first priority was better. After preparing the final map, through the study on areas with priority, we have screened and shown places that the standards are higher for locating KBT on the map. At last, for the best performance, we have paid special attention to factors such as proximity to universities and training centers, proximity to industrial areas, infrastructures and Tehran province’s development plans.