Gender bias in institutions represents a challenge to all women seeking equal participation and competing for leadership positions, as does the way that political and economic systems are organized. Scepticism and mistrust in women’s ability to lead, and the stereotypes and prejudices about their role in society and their lack of suitability for leadership roles and decision-making are other major challenges for all women especially for Alpha females who are capable of leadership. The present study was carried out to compare self-efficacy and social self-esteem in Alpha female students. Our statistical population included all female students of Kangavar Payame Noor University, out of which a sample of 300 subjects were selected using Quota sampling method. The tools administered were Ward, Popson and Dipaolo Alpha female inventory, Sherer self efficacy scale and Lawson, Marshal and McGrath social self esteem questionnaire. Results indicated that the mean of scores for alpha females was higher than Non-alpha females in self efficacy and social self esteem. In addition, the three subscales of the alpha female inventory (leadership, strength and low introversion) were positively related to self efficacy and social self-esteem. The results of this study endorse the relationship between leadership aptitude in female‚ students with self efficacy and social self-esteem (P<0.05).