One of the most important needs of any societies is to have thoughtful and efficient citizens in various social, political, cultural and economic fields. Achieving this goal depends on the enabling people in the community to construct knowledge and the development of skills such as critical thinking, self-leadership, creativity and innovation, inquiry and questioning, which also depends on creating an education system with a research-oriented approach. Therefore, the purpose of this study is to review the effect of Inquiry-Based Science education methods on knowledge construction and development of the mentioned skills in learners. The research method of this study was review. Among the articles published abroad, forty articles were collected from the databases of Science Direct, Google Scholar and Scopus, and in the section of domestic articles, the database of Scientific Information Database, Iran Research Institute for Information Science and Technology and the Institute for Humanities and Cultural Studies were used. A review of the collected resources showed that since through the Inquiry-Based Science Education method, learners are active during the education process, creation of problem-solving ability in them, leads to the discovery and construction of deep knowledge by learners and also has a positive effect on strengthen the learner's skills such as critical thinking, self-direction, creativity, inquiry and questioning. As a result, by using the Inquiry-Based Science Education, learners become effective citizens in order to advance the society. To achieve this important goal, educational systems must move from an education-oriented approach to a research-oriented approach.