Background and Objective: Life skills are abilities that grow with continued training and prepare the person to face with daily life issues, increasing mental, social and health abilities. The present study aimed to evaluate the student's life skills in Kurdistan University of Medical Sciences and its affecting factors. Materials and Methods: This was a cross-sectional study. Three hundred and eighty-five students of Kurdistan University of Medical Sciences were selected, randomly. Data gathering tool was a standard questionnaire which was including demographic information such as age, gender, degree of education, marital status, level of study, college and 57 questions in 7 areas of life skills. The collected data were analyzed using SPSS 20. ANOVA and T test were used to investigate the relationship between the dependent variable and other variables. Results: The total Mean score of students' life skills was 191. 71± 20. 30. There were no significant differences between gender, college and total score of life skills statistically (P=0. 49). There were significant differences between college, problem-solving, decision making (P=0. 049) and also creative thinking (P˂ 0. 0001). Conclusion: The findings showed that the life skills of the students were moderate. In order to improve the life skills of the students establishing workshops and recreational programs are suggested.