Introduction: Failure modes and effects analysis (FMEA) is one of many techniques for risk assessment that has used in this study in order to identify, assessment and offering appropriate measures for control, decrease and eliminate probable hazards related to use, maintenance and repair ventilators in Al-Zahra Hospital of Isfahan.Methods: This was a descriptive-cross sectional and applied research that the researcher determined the main components of the ventilator by observing the process and interview with staff and according to them, determined the process carefully and then using focus group discussion to identify potential failure modes and effects, the degrees of severity, occurrence, detection and risk priority number. To this end, the researcher used the standard worksheet of FMEA. After consulting with experts of equipment department, chief and nurses of hospital respiratory unit, proposed measures to decision making group and based on the degree of importance and constructability prioritized by the department director and his decisions was assessed based on decision table criterions of the research. Finally, based on the set priorities, the relevant proposal measures were submitted to the director.Results: Overall, 17 cases of the potential risk associated with ventilator in respiratory unit was detected that the highest risk priority number was related to the potential risk of failure to timely replace battery with a score of 225 and the lowest number by the score of 10 was related to the potential failure modes of pulling the power cord from the machine.Conclusion: Since a large part of the cost of hospitals is spent on purchase and maintenance of medical equipment' s, including equipment's such as ventilator, FMEA technique with its preventive approach can reduce these costs and assist hospitals in providing high quality services and achieving customer satisfaction.