Introduction: Patient safety is one of the main components of quality of health care implying preventing any damage to the patients during delivery of healthcare services. The main purpose of the healthcare systems is to protect and promote the health; therefore, patient safety is the major concern of these systems.The purpose of the present study was to develop strategies for improving patient safety in hospital.Methods: Fifty five individuals were enrolled in the survey, including the chief of the hospital, top and middle managers, and doctors and nurses with over ten years of experience in the target hospital. A researcher made questionnaire was used to collect data. The data were analyzed using descriptive statistics as well as analytical methods, including matrix of evaluation of external and internal factors, SWOT matrix, internal and external matrix and matrix of quantitative strategic planning.Results: Evaluation matrix of internal and external factors were 2.56 and 2.86, respectively. Based on the evaluation of these matrices, aggressive strategies were chosen.Using QSPM matrix, the chosen strategies were prioritized. The best strategy, i.e., development of the governance and leadership with score of 6.657 was chosen.Conclusions: Adopting aggressive strategies, especially in the areas of governance and leadership, can lead to an improved patient safety in hospital.