The purpose of this study was to identify the barriers of internationalization with organizational adaptation approach and then to present a model of exposure in Golestan University of Medical Sciences. The research was an applied study in terms of purpose and in terms of methodology, descriptive survey. The statistical population consisted of 373 managers and faculty members of Golestan University of Medical Sciences those were selected by stratified random sampling method based on Cochran formula. Afterwards, 190 members were selected as study participation. Data collection was perforemed thorugh a researcher made questionnaire of barriers to internationalization with 69 questions, a researcher made questionnaire of facilitators of internationalization with 71 questions and a researcher made questionnaire of organizational adaptability with 40 questions. The validity and reliability of the instruments were confirmed. Moreover, tests, exploratory factor analysis, confirmatory factor analysis and structural equations were used for data analysis. The results showed that the three barriers to internationalization included thirteen components: "cultural, teaching, content, human, equipment, structural, managerial-political, financial, technological, support services, international cooperation, internal barriers to the organization, and curriculum". Fourteen Components of Facilitating Internationalization: Document Accreditation, Knowledge Production, Access to Various Learning, Educational, Communication, Cultural, Political Resources, Higher Education Major Policies, Creating Professional Development Opportunities for Managers and Professors, scientific and cultural relations, current laws and their transparency, development of financial resources, development of resources, the origin and development of technological infrastructures. Barriers to university internationalization with standard coefficient (-0. 431) had a significant negative impact on organizational adaptability, in addition, internationalization facilitating factors of university with standard coefficient (0. 503) had a positive and significant effect on organizational adaptability; and therefore, the proposed model revealed an acceptable conformity.