Introduction: Manpower consider as the most valuable asset and resource organization in the world today. Job satisfaction is the main factor of employees’ job performance and it leads to increase productivity and satisfaction in individuals. Organizational managers in order to achieving ideal goal should present more comprehensive image of the jobs’ satisfaction employees. This study has been done to investigate Faculty members’ job satisfaction in GUMS. Methods: This descriptive-cross sectional study has been done on 186 basic sciences and clinical faculty members of medicine, dentistry, pharmacy, nursing& midwifery, paramedical and health school in Guilan university of medical sciences in the years 2018 to 2019. Reaserch tool was standard job satisfaction questionnaire of smith, kendall & Hulin in two parts including: personal information and questionnaire with 45 questions in 6 domains: salary &benefits, upgrade opportunities and personal growth, how to supervise and connections, psychological conditions and job security, physical conditions and the nature of work. Data were analyzed by statistical indicators frequency (percent), Mean (standard deviation) and kruskal-wallis, pearson correlation coefficient and linear regression tests through SPSS. Results: Findings show that the Mean score of different domains of job satisfaction was between 1 to 5 as follow: the nature of work (3. 9± 0. 8), management, how to supervise and connections (3. 3± 0. 7), physical conditions and the nature of work (3. 1± 0. 8) psychological conditions and job security (3. 1± 0. 9), upgrade opportunities and personal growth (3. 0± 0. 7) and salary &benefits (2. 8± 0. 8). Satisfaction in all domains was on average Mean except nature of work domain was desirable. Results of Pearson correlation test show that among satisfaction level and different domains, the most positive correlation respectively related to psychological conditions and job security, job management aspect(how to supervise and connections), upgrade opportunities and personal growth, physical conditions and the workplace, nature of work, salary &benefits (correlation coefficient between 0. 705 to 0. 905). Totally age, total years of service, type of employment and educational groups of faculty members, explain satisfaction variance score (3 to 18) in different domains. Conclusion: Satisfaction in all domains was moderate only in jobs’ nature was desirable. It is suggested in subsequent study the reasons of less satisfaction in young and junior faculties also in clinical faculties considered.