Introduction: Today, due to the dynamic environmental changes, higher education system, like other systems, requires change. Given the role of faculty members in the quality development of provided services by the university, identification the required capabilities can play a significant role in improving these services. The main purpose of this research is to developing a professional Capabilities Model to Talented Faculty Members at Comprehensive Universities with Regional Performance level. Methods: This is an applied & explanatory mixed method research. To this purpose, 19 knowledgeable academic and executive experts were selected purposefully and with a theoretical sampling strategy and interviewed in a semi-structured way. In the quantitative section, 13 interviewees answered the questionnaire. To analyze the data, the thematic analysis technique was used for qualitative section and one sample t-test in quantitative section as well. To ensure the validity of the research, reviewed by members (interviewees) and the triangulation of the data sources methods were used. Also, to calculate coding reliability, retest and the inter coder agreement reliability were used. Results: Scientific capability, research capability, The power of expression and content transmissions, The ability to provide an idea, class management, Ability to use the theory and practice, and professional consultation are important capabilities that comprehensive regional universities should pay attention to when selecting faculty members. Also, the results of t test (18. 66) indicated that the model had sufficient and appropriate reliability to predict faculty members' professional Capabilities (p<0. 01). Discussion: The results showed for selecting faculty members, Comprehensive universities with regional performance levels should pay particular attention to scientific, research, consulting, the power of expression, ideation, class management and applied theory in practice. The model was designed in this study can help to achieve this mission in these universities.