Family is important to both health and adolescence domains. There are few studies on Iranian adolescents' health, and even fewer on adolescents' perspectives on family-based health in a qualitative approach. Adolescence is commonly considered as a time of peak health, but there are some important family-based risk factors. The goal of the present research is to develop an analysis of the adolescents' perspectives on health and family. A content analysis has been done on adolescents' perspectives on health and family. Adolescents were interviewed with ethical issues being considered until the data became saturated. The analysis of adolescents' explanations revealed the following three categories: widening generation gap, parental responsibility in adolescents' health promotion, ineffective parenting, family economy and adolescents' health. Exploring adolescents' perspectives will be useful in creating a healthy future. Nowadays social factors affect familial situations in different respects and this will play a role in changing both the familys and adolescents' health. Both children and parents need more knowledge and better skills about adolescence health and development, and about social trends. Understanding adolescents and families in a more realistic way, parents should develop healthy communications and avoid familial health problems. Policy-makers, understanding both adolescents and families, can achieve the same goal. However, this issue requires further investigation.