VALERIANA OFFICINAL IS TOTAL EXTRACT AS ADJUNCTIVE THERAPY IN PATIENTS WITH REFRACTORY SYMPTOMATIC GENERALIZED EPILEPSY

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KARKHEYRAN S.; KEBRIAEIZADEH A.; PAKDAMAN H.; SOLTANINEZHAD K.

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Journal: Current Journal of Neurology Year:2005 | Volume:3 | Issue:9 Page(s): 51-65

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Information Journal Paper

Title

VALERIANA OFFICINAL IS TOTAL EXTRACT AS ADJUNCTIVE THERAPY IN PATIENTS WITH REFRACTORY SYMPTOMATIC GENERALIZED EPILEPSY

Author(s)

KARKHEYRAN S. | KEBRIAEIZADEH A. | PAKDAMAN H. | SOLTANINEZHAD K. | Issue Writer Certificate

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Abstract

This study evaluated the effects of total extract of valeriana officinal is as adjunctive therapy for generalized refractory epilepsy (medical, vagal nerve stimulation, not candidate for surgery). Patients with symptomatic epilepsy having refractory seizures despite treatment with other antiepileptic drugs, were eligible (n=13). This open-label study comprised a Base-line phase, an Escalation phase which valeriana extract was titrated to a target dose and a Maintenance phase during which doses of valeriana extract and other concomitant antiepileptic were maintained.Our results have shown that almost 73% of patients who completed study, experienced at least 25% reduction in seizure frequency during the Maintenance phase related to Base-line phase (p<0.05).

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APA: Copy

KARKHEYRAN, S., KEBRIAEIZADEH, A., PAKDAMAN, H., & SOLTANINEZHAD, K.. (2005). VALERIANA OFFICINAL IS TOTAL EXTRACT AS ADJUNCTIVE THERAPY IN PATIENTS WITH REFRACTORY SYMPTOMATIC GENERALIZED EPILEPSY. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), 3(9), 51-65. SID. https://sid.ir/paper/102782/en

Vancouver: Copy

KARKHEYRAN S., KEBRIAEIZADEH A., PAKDAMAN H., SOLTANINEZHAD K.. VALERIANA OFFICINAL IS TOTAL EXTRACT AS ADJUNCTIVE THERAPY IN PATIENTS WITH REFRACTORY SYMPTOMATIC GENERALIZED EPILEPSY. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY)[Internet]. 2005;3(9):51-65. Available from: https://sid.ir/paper/102782/en

IEEE: Copy

S. KARKHEYRAN, A. KEBRIAEIZADEH, H. PAKDAMAN, and K. SOLTANINEZHAD, “VALERIANA OFFICINAL IS TOTAL EXTRACT AS ADJUNCTIVE THERAPY IN PATIENTS WITH REFRACTORY SYMPTOMATIC GENERALIZED EPILEPSY,” CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), vol. 3, no. 9, pp. 51–65, 2005, [Online]. Available: https://sid.ir/paper/102782/en

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