@STUDY ON ANTIPHOSPHOLIPID ANTIBODIES IN YOUNG ADULT WITH CEREBRAL ISCHEMIA

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TALEBI M.; MAJIDI J.; ARAMI M.A.; SADR ALDINI S.A.

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Journal: Current Journal of Neurology Year:2006 | Volume:5 | Issue:13 Page(s): 26-34

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Title

@STUDY ON ANTIPHOSPHOLIPID ANTIBODIES IN YOUNG ADULT WITH CEREBRAL ISCHEMIA

Author(s)

TALEBI M. | MAJIDI J. | ARAMI M.A. | SADR ALDINI S.A. | Issue Writer Certificate

Keywords

CEREBRAL ISCHEMIAQ2

ANTIPHOSPHOLIPID ANTIBODYQ2

YOUNG ADULTQ2

Abstract

Background: Stroke in YOUNG ADULTs (15-45 y) is not common. More than 40 cause have been recognized for YOUNG ADULTs stroke. One less known etiology is arterial thrombosis due to ANTIPHOSPHOLIPID ANTIBODY. This study evaluates the frequency of antiphospholipid antibodies in an unselected young population with CEREBRAL ISCHEMIA, also ANTIPHOSPHOLIPID ANTIBODY positive stroke patients were compared with those without them regard to stroke characteristics.Materials and Methods: All admitted patients (15-45 years old) to Imam Khomeini Hospital during 2 years(2003-2004), who suffered CEREBRAL ISCHEMIA tested for antiphospholipid and anticardiolipin antibodies and compared with a matched sex and age group without CEREBRAL ISCHEMIA. From 47 patients with stroke Twenty five with age (37+/- 5Ay) had inclusion criteria for study, 40 controls (37.12+/- 5.8) were studied. In stroke group there were 14 women and 11 men and in control group there were 24 women and 16 men.The antibodies (both IgG and IgM classes) measured by standardized enzyme-linked immunosorbent assay (ELIZA).Results: About 7.5% of strokes occurred in subjects under 45 years. The prevalence of these antibodies in stroke patients was 24% compared to 5% in the controls (P=<0.05). Mean of all antibodies levels, except the ANTIPHOSPHOLIPID ANTIBODY IgG, were significantly high in stroke group. There was at least one prior cerebral event in 2 of 6 ischemic patients (33.3%) with high antibodies, and 2 of 19 (10.5%) without them had at least one stroke, the difference was not significant.Conclusion: We conclude that the prevalence of antiphospholipid antibodies is rather high in YOUNG ADULTs with CEREBRAL ISCHEMIA. These patients may have unrecognized systemic lupus erythematosus. The ANTIPHOSPHOLIPID ANTIBODY-positive stroke patients did not differ significantly from antibody-negative stroke patients with regard to stroke characteristics only for mild echocardiographic abnormalities (P= 0.047).

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APA: Copy

TALEBI, M., MAJIDI, J., ARAMI, M.A., & SADR ALDINI, S.A.. (2006). @STUDY ON ANTIPHOSPHOLIPID ANTIBODIES IN YOUNG ADULT WITH CEREBRAL ISCHEMIA. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), 5(13), 26-34. SID. https://sid.ir/paper/102827/en

Vancouver: Copy

TALEBI M., MAJIDI J., ARAMI M.A., SADR ALDINI S.A.. @STUDY ON ANTIPHOSPHOLIPID ANTIBODIES IN YOUNG ADULT WITH CEREBRAL ISCHEMIA. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY)[Internet]. 2006;5(13):26-34. Available from: https://sid.ir/paper/102827/en

IEEE: Copy

M. TALEBI, J. MAJIDI, M.A. ARAMI, and S.A. SADR ALDINI, “@STUDY ON ANTIPHOSPHOLIPID ANTIBODIES IN YOUNG ADULT WITH CEREBRAL ISCHEMIA,” CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), vol. 5, no. 13, pp. 26–34, 2006, [Online]. Available: https://sid.ir/paper/102827/en

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