ANTIPHOSPHOLIPID ANTIBODY IN STROKE IN YOUNG ADULTS: A STUDY ON 23 PATIENTS WITH TITER HIGHER THAN NORMAL IN ISFAHAN

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ZARE M.; SAADATNIA M.; HAGHIGHI S.

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Journal: Journal of Mazandaran University of Medical Sciences Year:2004 | Volume:13 | Issue:41 Page(s): 32-39

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Title

ANTIPHOSPHOLIPID ANTIBODY IN STROKE IN YOUNG ADULTS: A STUDY ON 23 PATIENTS WITH TITER HIGHER THAN NORMAL IN ISFAHAN

Author(s)

ZARE M. | SAADATNIA M. | HAGHIGHI S. | Issue Writer Certificate

Keywords

STROKEQ4

CEREBROVASCULAR DISORDERSQ4

ANTICARDIOPLIPID SYNDROMEQ4

ANTIBODIES-ANTICARDIOLIPINQ4

CARDIOLIPINSQ4

Abstract

Background and purpose: Of the agents involved in STROKE, is presence of antiphospholipid antibody in serum of the patients. In recent years, in addition to cardiolipin antibody (aCL) another antiphospholipid antibody (aPL) was identified as the predispousing factor of STROKE. In the present study, in addition to the identification of higher than normal level of aCL and aPL, prevalence rate of aCL and aPL in the under 45 years patients having ischemic STROKE has been investigated.Materials and methods : In a descriptive study done in 45 years ischemic STROKE patients referring to Isfahan Alzahrah hospitals, the aCL and aPL (IgM,IgG) titers were measured, then clinical, laboratory and demographic titers higher than normal were studied.Results: Of 114 patients, 23 (19.5%) had IgM and IgG titers of acL and apL higher than normal. Of these 18(15.3%) patients with aCL titer higher than normal, 7 was men and 16 women. Higher than normal of aCL of type IgM and IgG were in 15(65.2%) and 8(34.7%) respectively; and aPL of type IgM and IgG were in 19(82.6%) and 6(26%) respectively. In 5(21%) patients non-cardiolipin antibody titer was higher than normal,(aPL higher than normal and aCL was normal). Embolic and thrombotic STROKEs were observed in 7 and 16 patients respectively. History of previous STROKE was seen in 7 patients. Heart. Valvolar involvement was detected in 47% of the patients.Discussion: The results show that majoritiy of the under 45 years patients with ischemic STROKE in Iran have the antiphospholipid antibody titer higher than normal range and approximately 20% of the patients have non anti cardiolipin antibody higher than normal. High titer of IgM which is observed in more percentage of the patients in Iran corresponds with the data available in the non developed countries such an India which indicate to be due to infections and toxins as the acute accelerator of IgM which needs to be more investigated.

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APA: Copy

ZARE, M., SAADATNIA, M., & HAGHIGHI, S.. (2004). ANTIPHOSPHOLIPID ANTIBODY IN STROKE IN YOUNG ADULTS: A STUDY ON 23 PATIENTS WITH TITER HIGHER THAN NORMAL IN ISFAHAN . JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 13(41), 32-39. SID. https://sid.ir/paper/45177/en

Vancouver: Copy

ZARE M., SAADATNIA M., HAGHIGHI S.. ANTIPHOSPHOLIPID ANTIBODY IN STROKE IN YOUNG ADULTS: A STUDY ON 23 PATIENTS WITH TITER HIGHER THAN NORMAL IN ISFAHAN . JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2004;13(41):32-39. Available from: https://sid.ir/paper/45177/en

IEEE: Copy

M. ZARE, M. SAADATNIA, and S. HAGHIGHI, “ANTIPHOSPHOLIPID ANTIBODY IN STROKE IN YOUNG ADULTS: A STUDY ON 23 PATIENTS WITH TITER HIGHER THAN NORMAL IN ISFAHAN ,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 13, no. 41, pp. 32–39, 2004, [Online]. Available: https://sid.ir/paper/45177/en

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