STUDY ON ANTIPHOSPHOLIPID ANTIBODIES IN YOUNG ADULT WITH CEREBRAL ISCHEMIA

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TALEBI M.; MAJIDI J.; ARAMI M.; TALEBI A.

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Journal: Studies in Medical Sciences Year:2006 | Volume:17 | Issue:3 Page(s): 203-208

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Title

STUDY ON ANTIPHOSPHOLIPID ANTIBODIES IN YOUNG ADULT WITH CEREBRAL ISCHEMIA

Author(s)

TALEBI M. | MAJIDI J. | ARAMI M. | TALEBI A. | Issue Writer Certificate

Keywords

STROKEQ2

CEREBRAL ISCHEMIAQ3

ANTIPHOSPHOLIPID ANTIBODYQ3

YOUNG ADULTSQ3

Abstract

Background and Aims: STROKE in YOUNG ADULTS (15-45 y) is not unusual. More than 40 causes have been recognized for YOUNG ADULTS STROKE. One less known etiology is arterial thrombosis due to ANTIPHOSPHOLIPID ANTIBODY. This study evaluates the frequency of antiphospholipid antibodies in an unselected young population with CEREBRAL ISCHEMIA; moreover, ANTIPHOSPHOLIPID ANTIBODY-positive STROKE patients were compared with those showingno STROKE characteristics.Materials and Methods: All admitted patients (15-45 years old) to Imam Khomeini Hospital 2003-2004, who suffered CEREBRAL ISCHEMIA were tested for antiphospholipid and anticardiolipin antibodies and compared with a matched sex and age group without CEREBRAL ISCHEMIA. Twenty five patients with STROKE (37+/-5.4y) and 40 controls (37.12+/- 5.8) were studied. In STROKE group there were 14 women and 11 men (60% female). The antibodies (both IgG and IgM classes) were measured by standardized enzyme-linked immunosorbent assay (ELIZA).Results: About 7.5% of STROKEs occurred in subjects under 45 years old. The prevalence of these antibodies in STROKE patients was 24% compared to 5% in the controls (p=<0.05). Mean of all antibodies' levels, except the ANTIPHOSPHOLIPID ANTIBODY IgG, were significantly high in the STROKE group. There was at least one prior cerebral event in 2 of 6 ischemic patients (33.3%) with high antibodies, and 2 of 19 (10.5%) without them; the change was not that much significant.Discussion: We conclude that the prevalence of antiphospholipid antibodies is rather high in YOUNG ADULTS with CEREBRAL ISCHEMIA. These patients may have unrecognized systemic lupus erythematosus. The ANTIPHOSPHOLIPID ANTIBODY-positive STROKE patients did not differ significantly from antibody-negative STROKE patients with regard to STROKE characteristics only for mild echocardiographic abnormalities (p= 0.047).

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APA: Copy

TALEBI, M., MAJIDI, J., ARAMI, M., & TALEBI, A.. (2006). STUDY ON ANTIPHOSPHOLIPID ANTIBODIES IN YOUNG ADULT WITH CEREBRAL ISCHEMIA. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 17(3), 203-208. SID. https://sid.ir/paper/64059/en

Vancouver: Copy

TALEBI M., MAJIDI J., ARAMI M., TALEBI A.. STUDY ON ANTIPHOSPHOLIPID ANTIBODIES IN YOUNG ADULT WITH CEREBRAL ISCHEMIA. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2006;17(3):203-208. Available from: https://sid.ir/paper/64059/en

IEEE: Copy

M. TALEBI, J. MAJIDI, M. ARAMI, and A. TALEBI, “STUDY ON ANTIPHOSPHOLIPID ANTIBODIES IN YOUNG ADULT WITH CEREBRAL ISCHEMIA,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 17, no. 3, pp. 203–208, 2006, [Online]. Available: https://sid.ir/paper/64059/en

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