Synthesis and in Vitro Evaluation of Antifungal and Antibacterial Activity of 2, 3-Dihydroquinazolinone Derivatives

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TAMADDON FATEMEH; Moradi Behnoosh; NASIRI ALIREZA; Rahbar Fatemeh

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Journal: TOLOO-E-BEHDASHT Year:2018 | Volume:17 | Issue:3 (69) Page(s): 77-85

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Title

Synthesis and in Vitro Evaluation of Antifungal and Antibacterial Activity of 2, 3-Dihydroquinazolinone Derivatives

Author(s)

TAMADDON FATEMEH | Moradi Behnoosh | NASIRI ALIREZA | Rahbar Fatemeh | Issue Writer Certificate

Keywords

Anti-bacterialQ1

Anti-fungalQ1

DihydroquinazolinoneQ1

Abstract

Introduction: By development of bacterial drug-resistance to traditional antibacterial drugs and fungal infections, the need to design, synthesis, and use of new and effective antibacterial and antifungal drugs is increased. Quinazolinone derivatives are heterocyclic compounds with nitrogen atoms that have pharmacological properties such as Anti-bacterial, anti-tumor, anti-inflammatory and antifungal properties. The aim of this study was to synthesize of new derivatives of Dihydroquinazolinone and study of their antibacterial and antifungal properties. Methods: This research is an experimental work in which four Dihydroquinazolinone derivatives were synthesized, by a new environmental-safe method and identified by various spectroscopic methods. Antibacterial activities of these derivatives were investigated against Escherichia coli gram-negative, and bacillus subtilis gram-positive in comparesion with amikacin. Antifungal activities of these derivatives were investigated against Aspergillusniger fungus and compared with ketoconazole. Both of antifungal and antibacterial activities of these synthetic compounds derivatives was checked by disk diffusion method with measuring the zone inhibition. Results: All synthetic Dihydroquinazolinones that were synthesized in high yields and purity, showed good antibacterial and antifungal properties. The compound 1d 2-phenyl-2, 3-dihydroquinazolin-4(1H)-one derivative of these compounds showed more antimicrobial activitiesand antifungal comparable with the Amikacin and Ketoconazole standard antibacterial and antifungal drugs. Conclusion: Synthetic Dihydroquinazolinone derivatives in this work have good antifungal and antibacterial activities. The higher antifungal and antibacterial activity of 2-phenyl-2, 3-dihydroquinazolin-4(1H)-one derivative can be related to more hydrophobicity of the phenyl group as a substitution in position 2.

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APA: Copy

TAMADDON, FATEMEH, Moradi, Behnoosh, NASIRI, ALIREZA, & Rahbar, Fatemeh. (2018). Synthesis and in Vitro Evaluation of Antifungal and Antibacterial Activity of 2, 3-Dihydroquinazolinone Derivatives. TOLOO-E-BEHDASHT, 17(3 (69) ), 77-85. SID. https://sid.ir/paper/102984/en

Vancouver: Copy

TAMADDON FATEMEH, Moradi Behnoosh, NASIRI ALIREZA, Rahbar Fatemeh. Synthesis and in Vitro Evaluation of Antifungal and Antibacterial Activity of 2, 3-Dihydroquinazolinone Derivatives. TOLOO-E-BEHDASHT[Internet]. 2018;17(3 (69) ):77-85. Available from: https://sid.ir/paper/102984/en

IEEE: Copy

FATEMEH TAMADDON, Behnoosh Moradi, ALIREZA NASIRI, and Fatemeh Rahbar, “Synthesis and in Vitro Evaluation of Antifungal and Antibacterial Activity of 2, 3-Dihydroquinazolinone Derivatives,” TOLOO-E-BEHDASHT, vol. 17, no. 3 (69) , pp. 77–85, 2018, [Online]. Available: https://sid.ir/paper/102984/en

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