The effects of cytotoxic thyroid hormone T4 on proliferation of brain glioblastoma cells (A172) in vitro

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AHMADI RAHIM; Sagharjoghi Farahani Morteza; Khodadadi Babak

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Journal: Razi Journal of Medical Sciences Year:2018 | Volume:25 | Issue:166 Page(s): 58-66

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Information Journal Paper

Title

The effects of cytotoxic thyroid hormone T4 on proliferation of brain glioblastoma cells (A172) in vitro

Author(s)

AHMADI RAHIM | Sagharjoghi Farahani Morteza | Khodadadi Babak | Issue Writer Certificate

Keywords

CytotoxicQ2

Thyroid Hormones T4Q1

A172 CellsQ1

Abstract

Background: Studies showed thyroid hormones influence proliferation of cancer cells. The main aim of this study was to investigate the effects of Cytotoxic thyroid hormone T4 on proliferation of brain glioblastoma cells (A172) in cell culture. Methods: In this laboratory experimental study, A172 Cells were randomly divided into control group and groups exposed to doses 0. 1, 0. 5, 1, 5, 10, 20, 40, 50 Lambda (λ ) of thyroid hormone T4. The toxic effect of hormones was measured using MTT assay method. The data were statistically analyzed between groups using ANOVA. Results: The result demonstrated that highest toxicity of thyroid hormone T4 on glioblastoma cancer cells A172 was in 1 lambda (λ ) dosage and low toxicity in 0. 1 and 40 lambdas (λ ) dosages. Conclusion: Toxicity of Glioblastoma cancer cells is either hormone dependent or hormone independent.

Cites

The effect of T4 thyroid hormone proliferation on U87 brain glioblastoma cells

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APA: Copy

AHMADI, RAHIM, Sagharjoghi Farahani, Morteza, & Khodadadi, Babak. (2018). The effects of cytotoxic thyroid hormone T4 on proliferation of brain glioblastoma cells (A172) in vitro. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 25(166 ), 58-66. SID. https://sid.ir/paper/10381/en

Vancouver: Copy

AHMADI RAHIM, Sagharjoghi Farahani Morteza, Khodadadi Babak. The effects of cytotoxic thyroid hormone T4 on proliferation of brain glioblastoma cells (A172) in vitro. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2018;25(166 ):58-66. Available from: https://sid.ir/paper/10381/en

IEEE: Copy

RAHIM AHMADI, Morteza Sagharjoghi Farahani, and Babak Khodadadi, “The effects of cytotoxic thyroid hormone T4 on proliferation of brain glioblastoma cells (A172) in vitro,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 25, no. 166 , pp. 58–66, 2018, [Online]. Available: https://sid.ir/paper/10381/en

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