THE SIMULTANEOUS EFFECT OF REGULAR EXERCISE AND VITAMIN D ON NF-κBP65 LEVELS IN MALE RATS EXPOSED TO HYDROGEN PEROXIDE

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MOHSENIZADEH NAEMEH; AZARBAYJANI MOHAMMAD ALI; NAJAFIPOUR HAMID; MATIN HOMAEE HASAN; KESHTKAR ABBASALI

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Journal: KNOWLEDGE AND HEALTH Year:2017 | Volume:12 | Issue:3 Page(s): 55-62

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Title

THE SIMULTANEOUS EFFECT OF REGULAR EXERCISE AND VITAMIN D ON NF-κBP65 LEVELS IN MALE RATS EXPOSED TO HYDROGEN PEROXIDE

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MYOCARDIAL INFLAMMATIONQ2

OXIDATIVE STRESSQ2

NF-κB P65Q2

REGULAR EXERCISE ACTIVITYQ2

VITAMIN DQ2

Abstract

Introduction: OXIDATIVE STRESS and inflammation are involved in common signaling pathways and play central role in heart functions and disorders. Factor kappa-B p65 (NF-kBp65), is an important marker of MYOCARDIAL INFLAMMATION. This study investigated the combination of regular exercise (E), VITAMIN D (VD) and OXIDATIVE STRESS induced on the levels of NF-kBp65 in the myocardium.Methods: 60 adult male rats of the Wistar race were randomly divided into 10 groups: control; H2O2; 2H2O2; H2O2+VD3; 2H2O2+VD3; H2O2+E; 2H2O2+E; H2O2+VD3+E; 2H2O2+VD3+E and dimethyl sulfoxide + saline that were under the intervention protocol for 8 weeks. An ELISA kit used to measure NF-kBp65 concentration. Data were analyzed three-way ANOVA. Significant level was set at 0.05.Results: The results showed the Exercise had a decrease effect on NF-kBp65 protein concentration (P=0.049). Also, high concentration of H2O2 increased the NF_kBp65 protein concentration (P=0.013). On the other hand, the interaction of E and VD had decreasing effect on NF-kBp65 protein concentration (P=0.004). However, VD and E interaction with H2O2 were not significant. Coincidence of three interventions E, H2O2 and VD compared to the combined effect of each one, had a decreasing effect on the protein concentration of NF-kBp65 (P=0.038).Conclusion: It seems that REGULAR EXERCISE ACTIVITY, VD antioxidant and exogenous induction of OXIDATIVE STRESS can be used to preconditioning and reduce MYOCARDIAL INFLAMMATION in high OXIDATIVE STRESS conditions.

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APA: Copy

MOHSENIZADEH, NAEMEH, AZARBAYJANI, MOHAMMAD ALI, NAJAFIPOUR, HAMID, MATIN HOMAEE, HASAN, & KESHTKAR, ABBASALI. (2017). THE SIMULTANEOUS EFFECT OF REGULAR EXERCISE AND VITAMIN D ON NF-κBP65 LEVELS IN MALE RATS EXPOSED TO HYDROGEN PEROXIDE. KNOWLEDGE AND HEALTH, 12(3 ), 55-62. SID. https://sid.ir/paper/107820/en

Vancouver: Copy

MOHSENIZADEH NAEMEH, AZARBAYJANI MOHAMMAD ALI, NAJAFIPOUR HAMID, MATIN HOMAEE HASAN, KESHTKAR ABBASALI. THE SIMULTANEOUS EFFECT OF REGULAR EXERCISE AND VITAMIN D ON NF-κBP65 LEVELS IN MALE RATS EXPOSED TO HYDROGEN PEROXIDE. KNOWLEDGE AND HEALTH[Internet]. 2017;12(3 ):55-62. Available from: https://sid.ir/paper/107820/en

IEEE: Copy

NAEMEH MOHSENIZADEH, MOHAMMAD ALI AZARBAYJANI, HAMID NAJAFIPOUR, HASAN MATIN HOMAEE, and ABBASALI KESHTKAR, “THE SIMULTANEOUS EFFECT OF REGULAR EXERCISE AND VITAMIN D ON NF-κBP65 LEVELS IN MALE RATS EXPOSED TO HYDROGEN PEROXIDE,” KNOWLEDGE AND HEALTH, vol. 12, no. 3 , pp. 55–62, 2017, [Online]. Available: https://sid.ir/paper/107820/en

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