Involvement of Basolateral Amygdala Dopamine D1 Receptors in the Acquisition and Expression of Morphine-Induced Place Preference in Rats

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REZAEI ZAHRA; ALAEI HOJJATALLAH; REISI PARHAM

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Journal Paper

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Journal: Advanced Biomedical Research Year:2022 | Volume:11 | Issue:- Page(s): 0-0

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Information Journal Paper

Title

Involvement of Basolateral Amygdala Dopamine D1 Receptors in the Acquisition and Expression of Morphine-Induced Place Preference in Rats

Author(s)

REZAEI ZAHRA | ALAEI HOJJATALLAH | REISI PARHAM | Issue Writer Certificate

Keywords

Addiction

basolateral amygdala

dopamine-D1 receptor

morphine

Abstract

Background: In the present study, the effects of intra‑, basolateral amygdala (BLA) blockade of dopamine D1 receptor on morphine‑, induced conditioned place preference (CPP) were investigated in male Wistar rats. Materials and Methods: A 5‑, day CPP paradigm was used. morphine was injected subsequently at effective (5 mg/kg) and ineffective (0. 5 mg/kg) doses. SCH 23390 (0. 5–,μ, g/rat), as a selective D1 receptor antagonist, was microinjected bilaterally into the BLA. Results: Effective dose of morphine induced a significant CPP, and increased the locomotor activity during the testing phase. The results showed that morphine‑, induced CPP was significantly suppressed by D1 receptors antagonist in BLA in the acquisition phase and caused an aversion even at high doses. The antagonist also significantly prevented CPP expression. morphine increased the motor activity, but the D1 receptors blockade, significantly reduced it. Conclusions: The findings of this study suggest a possible role for BLA dopamine D1 receptors in reward responses in morphine dependency.

Cites

The electrical stimulation of the central nucleus of the amygdala in combination with dopamine receptor antagonist reduces the acquisition phase of morphine-induced conditioned place preference in male rat

References

Dopamine: The neuromodulator of long-term synaptic plasticity, reward and movement control

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APA: Copy

REZAEI, ZAHRA, ALAEI, HOJJATALLAH, & REISI, PARHAM. (2022). Involvement of Basolateral Amygdala Dopamine D1 Receptors in the Acquisition and Expression of Morphine-Induced Place Preference in Rats. ADVANCED BIOMEDICAL RESEARCH, 11(-), 0-0. SID. https://sid.ir/paper/1117109/en

Vancouver: Copy

REZAEI ZAHRA, ALAEI HOJJATALLAH, REISI PARHAM. Involvement of Basolateral Amygdala Dopamine D1 Receptors in the Acquisition and Expression of Morphine-Induced Place Preference in Rats. ADVANCED BIOMEDICAL RESEARCH[Internet]. 2022;11(-):0-0. Available from: https://sid.ir/paper/1117109/en

IEEE: Copy

ZAHRA REZAEI, HOJJATALLAH ALAEI, and PARHAM REISI, “Involvement of Basolateral Amygdala Dopamine D1 Receptors in the Acquisition and Expression of Morphine-Induced Place Preference in Rats,” ADVANCED BIOMEDICAL RESEARCH, vol. 11, no. -, pp. 0–0, 2022, [Online]. Available: https://sid.ir/paper/1117109/en

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