IDENTIFICATION AND QUANTIFICATION OF GLICLAZIDE IN HUMAN PLASMA BY HPLC-PDA

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SABERI MEISAM; RAMEZANI ZAHRA; SABERI ALI HOSSEIN; RASHIDI HOMEIRA

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Paper Information

Journal: Jundishapur Scientific Medical Journal Year:2018 | Volume:17 | Issue:2 Page(s): 195-201

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Title

IDENTIFICATION AND QUANTIFICATION OF GLICLAZIDE IN HUMAN PLASMA BY HPLC-PDA

Author(s)

SABERI MEISAM | RAMEZANI ZAHRA | SABERI ALI HOSSEIN | RASHIDI HOMEIRA | Issue Writer Certificate

Keywords

HPLCQ1

HPLC-PDAQ1

GLICLAZIDEQ1

Abstract

Background and Objective: In this study, a high-performance liquid chromatography method was developed to determine the concentration of GLICLAZIDE in plasma. The Photodiode array (PDA) detector allows for the determination of purity.Subjects and Methods: The mobile phase used in this study was phosphate buffer with pH=3.5 and acetonitrile (HPLC grade) at a ratio of 1: 1 was run isocraticaly through a C18 analytical column. The UV detection was done at 253 nm. Analytical run time was less than 10 min.Results: In the optimum conditions, the calibration curve in the area of 50 to 400 ng/ml, linear with the equation y=28.029x+212.74 and 0.998=R2. GLICLAZIDE was detected within 3.6 minutes by photodiode detector. The limit of detection (LOD) and the limit of quantitative (LOQ) in this method are calculated as 23 ng/ml and 71 ng/ml, respectively.Conclusion: The evaluation of the accuracy and precision of method showed that this method has the ability to determine the amount of GLICLAZIDE in plasma, and the method is reliable and fast.

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APA: Copy

SABERI, MEISAM, RAMEZANI, ZAHRA, SABERI, ALI HOSSEIN, & RASHIDI, HOMEIRA. (2018). IDENTIFICATION AND QUANTIFICATION OF GLICLAZIDE IN HUMAN PLASMA BY HPLC-PDA. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 17(2 ), 195-201. SID. https://sid.ir/paper/12214/en

Vancouver: Copy

SABERI MEISAM, RAMEZANI ZAHRA, SABERI ALI HOSSEIN, RASHIDI HOMEIRA. IDENTIFICATION AND QUANTIFICATION OF GLICLAZIDE IN HUMAN PLASMA BY HPLC-PDA. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2018;17(2 ):195-201. Available from: https://sid.ir/paper/12214/en

IEEE: Copy

MEISAM SABERI, ZAHRA RAMEZANI, ALI HOSSEIN SABERI, and HOMEIRA RASHIDI, “IDENTIFICATION AND QUANTIFICATION OF GLICLAZIDE IN HUMAN PLASMA BY HPLC-PDA,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 17, no. 2 , pp. 195–201, 2018, [Online]. Available: https://sid.ir/paper/12214/en

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