CLINICAL EFFECT OF PREMEDICATION WITH SINGLE-DOSE ORAL PREGABALIN ON PAIN PERCEPTION AND HEMODYNAMIC VARIATIONS AFTER SURGICAL REMOVAL OF IMPACTED MOLARS

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EFTEKHARIAN HAMIDREZA; ARBIYUN HAMIDREZA; EGHBALI LADAN; HOSEININEJAD LEYLA

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Journal: Journal of Isfahan Dental School Year:2014 | Volume:10 | Issue:4 Page(s): 237-248

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Title

CLINICAL EFFECT OF PREMEDICATION WITH SINGLE-DOSE ORAL PREGABALIN ON PAIN PERCEPTION AND HEMODYNAMIC VARIATIONS AFTER SURGICAL REMOVAL OF IMPACTED MOLARS

Author(s)

EFTEKHARIAN HAMIDREZA | ARBIYUN HAMIDREZA | EGHBALI LADAN | HOSEININEJAD LEYLA | Issue Writer Certificate

Keywords

PREGABALINQ2

PAINQ3

SURGERYQ2

THIRD MOLARQ2

Abstract

Introduction: PAIN and hemodynamic changes are common complications of surgeries on impacted THIRD MOLARs. In this study, the effect of premedication with a 75-mg dose of PREGABALIN on hemodynamic changes and postoperative PAIN was evaluated.Materials and Methods: In this double-blind randomized clinical trial, 210 patients who needed surgical removal of impacted wisdom teeth were selected. The subjects were randomly assigned to two groups. The experimental group (n=105) received 75 mg of PREGABALIN orally one hour before the operation. Placebo was prescribed for patients in the control group (n=98). Hemodynamic changes were assessed in four stages: stage 1: one hour before SURGERY and before premedication; stage 2: immediately before SURGERY and after injection of anesthetic agent; stage 3: after SURGERY; and stage 4: 6 hours after SURGERY. PAIN intensity was measured with visual analog scale (VAS). Data were analyzed with SPSS 15, using ANCOVA and Mann-Whitney U test (a=0.05).Results: Mean heart rates at stages 2, 3 and 4 revealed significant differences after adjusting for age (p value<0.001). Mean systolic pressure changes at stages 2, 3 and 4 in the case group were more unfavorable compared to the control group (p value<0.001). Mean diastolic pressure changes at stages 2, 3 and 4 were significantly different between the two groups (p value<0.05). Mean diastolic pressure decreased in the test group, with no changes in the control group. Postoperative PAIN in the control group was significantly more severe in the control group compared to the case group (p value<0.001).Conclusion: Considering the limitations of this study, premedication with oral PREGABALIN with a dose of 75 mg in impacted THIRD MOLAR SURGERY has a significant effect on reducing systolic and diastolic pressures and is effective in reducing postoperative PAIN scores.

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APA: Copy

EFTEKHARIAN, HAMIDREZA, ARBIYUN, HAMIDREZA, EGHBALI, LADAN, & HOSEININEJAD, LEYLA. (2014). CLINICAL EFFECT OF PREMEDICATION WITH SINGLE-DOSE ORAL PREGABALIN ON PAIN PERCEPTION AND HEMODYNAMIC VARIATIONS AFTER SURGICAL REMOVAL OF IMPACTED MOLARS. JOURNAL OF ISFAHAN DENTAL SCHOOL, 10(4), 237-248. SID. https://sid.ir/paper/126097/en

Vancouver: Copy

EFTEKHARIAN HAMIDREZA, ARBIYUN HAMIDREZA, EGHBALI LADAN, HOSEININEJAD LEYLA. CLINICAL EFFECT OF PREMEDICATION WITH SINGLE-DOSE ORAL PREGABALIN ON PAIN PERCEPTION AND HEMODYNAMIC VARIATIONS AFTER SURGICAL REMOVAL OF IMPACTED MOLARS. JOURNAL OF ISFAHAN DENTAL SCHOOL[Internet]. 2014;10(4):237-248. Available from: https://sid.ir/paper/126097/en

IEEE: Copy

HAMIDREZA EFTEKHARIAN, HAMIDREZA ARBIYUN, LADAN EGHBALI, and LEYLA HOSEININEJAD, “CLINICAL EFFECT OF PREMEDICATION WITH SINGLE-DOSE ORAL PREGABALIN ON PAIN PERCEPTION AND HEMODYNAMIC VARIATIONS AFTER SURGICAL REMOVAL OF IMPACTED MOLARS,” JOURNAL OF ISFAHAN DENTAL SCHOOL, vol. 10, no. 4, pp. 237–248, 2014, [Online]. Available: https://sid.ir/paper/126097/en

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